Amrinone

Base Information Edit

Chemical Name:Amrinone
CAS No.:60719-84-8
Molecular Formula:C10H9N3O
Molecular Weight:187.201
Hs Code.:29333999
European Community (EC) Number:262-390-0
NSC Number:759805
UNII:JUT23379TN
DSSTox Substance ID:DTXSID9022603
Nikkaji Number:J17.949C
Wikipedia:Amrinone
Wikidata:Q422724
NCI Thesaurus Code:C61789
Pharos Ligand ID:DCWWW3BX6XVT
Metabolomics Workbench ID:43556
ChEMBL ID:CHEMBL12856
Mol file:60719-84-8.mol

Synonyms:5-Amino-(3,4'-bipyridine)-6(1H)-one;Amrinon;Amrinone;Cordemcura;Inocor;Win 40680;Win-40680;Win40680;Wincoram

Suppliers and Price of Amrinone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Amrinone
1g
$ 403.00

TRC
Amrinone
50mg
$ 55.00

TRC
Amrinone
500mg
$ 95.00

Sigma-Aldrich
Amrinone
1g
$ 180.00

Sigma-Aldrich
Amrinone United States Pharmacopeia (USP) Reference Standard
500mg
$ 350.00

Medical Isotopes, Inc.
Amrinone
1 g
$ 590.00

DC Chemicals
Amrinone >98%
1 g
$ 300.00

Crysdot
Amrinone 97%
5g
$ 331.00

ChemScene
Amrinone ≥98.0%
100mg
$ 85.00

ChemScene
Amrinone ≥98.0%
25mg
$ 35.00

Total 119 raw suppliers

Chemical Property of Amrinone Edit

Chemical Property:

Appearance/Colour:Crystalline solid
Vapor Pressure:2.42E-08mmHg at 25°C
Melting Point:294-297 °C (dec.)
Refractive Index:1.625
Boiling Point:451.5 °C at 760 mmHg
PKA:12.05±0.10(Predicted)
Flash Point:226.9 °C
PSA：71.77000
Density:1.277 g/cm³
LogP:1.60030
Storage Temp.:2-8°C
Water Solubility.:Insoluble in water or chloroform. Slightly soluble in acetic acid or DMF. Soluble in DMSO
XLogP3:-0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:187.074561919
Heavy Atom Count:14
Complexity:301

Purity/Quality:

99% ^*data from raw suppliers

Amrinone ^*data from reagent suppliers

Safty Information:

Pictogram(s): T, Xn
Hazard Codes:T,Xn
Statements: 25-36/37/38-20/21/22
Safety Statements: 28-45-36-26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=CC=C1C2=CNC(=O)C(=C2)N
Description Amrinone is a positive inotropic agent useful in the management of severe congestive heart failure. It is effective even in unresponsive, fully digitalized patients. Amrinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 19.5 μM). It increases developed tension and contractile force in isolated cat papillary muscle. Amrinone (1-10 mg/kg) has positive inotropic effects, increasing the rate and force of heart contraction in anesthetized and unanesthetized dogs.
Uses A selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. Cardiotonic Amrinone is used for short-term treatment of cardiac insufficiency that does not respond to treatment of other drugs.
Therapeutic Function Cardiotonic

Technology Process of Amrinone

There total 12 articles about Amrinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 934200-37-0
C₁₈H₁₅N₃O₃

: 60719-84-8
amrinone

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; at 20 ℃;

Reference yield: 84.0%

: 62749-46-6
5-(pyridin-4-yl)-3-carbamoyl-pyridine-2(1H)-one

: 60719-84-8
amrinone

Guidance literature:: With sodium hypochlorite; sodium sulfite; In sodium hydroxide; 1) 30 deg C, 15 min; 40 deg C, 15 min, 2) 40 deg C, 20 min;