2-Hydrazinopyridine

Base Information

• Chemical Name: 2-Hydrazinopyridine
• CAS No.: 4930-98-7
• Molecular Formula: C5H7N3
• Molecular Weight: 109.131
• Hs Code.: 2933990090
• European Community (EC) Number: 225-566-8
• NSC Number: 76877
• UNII: X2NH3RN7C3
• DSSTox Substance ID: DTXSID5063651
• Nikkaji Number: J207K
• Wikidata: Q72482876
• Mol file: 4930-98-7.mol

Synonyms:2-hydrazinopyridine;2-pyridinylhydrazine

Chemical Property of 2-Hydrazinopyridine

Chemical Property:

• Appearance/Colour: White to light beige low melting solid
• Vapor Pressure: 0.00715mmHg at 25°C
• Melting Point: 41-44 °C(lit.)
• Refractive Index: 1.657
• Boiling Point: 269.7 °C at 760 mmHg
• PKA: 9.72±0.70(Predicted)
• Flash Point: 127 °C
• PSA: 50.94000
• Density: 1.222 g/cm³
• LogP: 1.14050
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 109.063997236
• Heavy Atom Count: 8
• Complexity: 64.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydrazinylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=NC(=C1)NN

Technology Process of 2-Hydrazinopyridine

There total 15 articles about 2-Hydrazinopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-pyridine (109-04-6) → pyrid-2-ylhydrazine (4930-98-7)

Guidance literature:

With hydrazine; at 100 ℃; for 2h;

DOI:10.3987/com-99-8760

Reference yield: 95.8%

2-chloropyridine (109-09-1) → pyrid-2-ylhydrazine (4930-98-7)

Guidance literature:

With hydrazine hydrate; In butan-1-ol; at 100 ℃; for 0.0277778h; Flow reactor; Large scale;

Reference yield:

E-pyridine-2-carbaldehyde 2-pyridylhydrazone (21945-37-9,2215-33-0) + phenylhydrazine (100-63-0) → pyrid-2-ylhydrazine (4930-98-7) + (E)-1-(2-pyridinyl)methylene-2-phenylhydrazine (30915-38-9)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In d⁽⁴⁾-methanol; at 45 ℃; for 6h;

DOI:10.1002/chem.201002308

upstream raw materials:

pyridine

2-chloropyridine

2-bromo-pyridine

pyridine-2-sulfonic acid

Downstream raw materials:

2-diphenylphosphinohydrazinopyridine

1-(4-nitrophenyl)-5-phenyl-4-[phenyl(pyridin-2-ylhydrazono)methyl]-1H-pyrazole-3-carboxylic acid

2-[3-(4-butoxyphenyl)pyrazol-1-yl]pyridine

[1-(N'-pyridin-2-yl-hydrazinocarbonyl)-ethyl]-carbamic acid tert-butyl ester

Refernces

• 1、 Gandikota, N. Murthy,Bolla, R. Sekhar,Viswanath, I. V. Kasi,Bethi, Sridharreddy. "A facile synthesis of amide derivatives of [1,2,4]triazolo[4,3-a]pyridine". . p. 1920 - 1924. Retrieved 2017.
• 2、 Dhavan, Pratik P.,Jadhav, Bhaskar L.,Manjare, Sudesh T.,Shelar, Divyesh S.,Singh, Pinky R.,Vaidya, Shashikant P.. "Synthesis and study of organoselenium compound: DNA/Protein interactions, in vitro antibacterial, antioxidant, anti-inflammatory activities and anticancer activity against carcinoma cells". . . Retrieved 2021/07/25.
• 3、 -. "Method for industrially producing bromo-pyrazolidinic acid through micro-channel". Paragraph 0085-0087; 0094-0096; 0116-0117. . Retrieved 2020/08/02.