N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide

Base Information

• Chemical Name: N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide
• CAS No.: 63979-60-2
• Molecular Formula: C₁₆H₃₃NO₄
• Molecular Weight: 303.442
• Hs Code.: 2924199090
• Mol file: 63979-60-2.mol

Synonyms:2-Hydroxymethyl-2-lauroylamino-propan-1,3-diol;USAF ND-75;T550;

Chemical Property of N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide

Chemical Property:

• Vapor Pressure: 8.69E-14mmHg at 25°C
• Boiling Point: 537.3°Cat760mmHg
• Flash Point: 278.8°C
• PSA: 93.28000
• Density: 1.042g/cm³
• LogP: 2.57950

Purity/Quality:

97% ^*data from raw suppliers

DODECANOIC ACID-(2-HYDROXY-1,1-BISHYDROXY METHYLETHYL)AMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide

There total 6 articles about N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]dodecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

β-Keto tridecanol (99224-14-3) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → N-Tris(hydroxymethyl)methyldodecanecarboxamide (63979-60-2)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In pyridine; for 5h; Heating;

DOI:10.1055/s-2000-7105

Reference yield: 69.0%

N-[tris(tert-butyldimethylsilyloxymethyl)methyl]dodecamide (1146965-61-8) → N-Tris(hydroxymethyl)methyldodecanecarboxamide (63979-60-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 46.0%

n-dodecanoyl chloride (112-16-3) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → N-Tris(hydroxymethyl)methyldodecanecarboxamide (63979-60-2)

Guidance literature:

With triethylamine; In methanol; at 12 - 14 ℃;

DOI:10.1021/acs.inorgchem.9b03407

upstream raw materials:

β-Keto tridecanol

2-amino-2-hydroxymethyl-1,3-propanediol

lauric acid

N-[tris(tert-butyldimethylsilyloxymethyl)methyl]dodecamide

Refernces

• 1、 West, Jonathan J.,Bonsergent, Guenola,Mackenzie, Grahame,Ewing, David F.,Goodby, John W.,Benvegnu, Thierry,Plusquellec, Daniel,Bachir, Sabrina,Bault, Phillipe,Douillet, Olivier,Gode, Paul,Goethals, Gerard,Martin, Patrick,Villa, Pierre. "The effect of molecular shape and microphase segregation on the formation of liquid crystal phases in poly-ols". . p. 23 - 44. Retrieved 2001.
• 2、 Megarajan, Sengan,Subramaniyan, Siva Bala,Muthuswamy, Sureshan,Anthony, Savarimuthu Philip,Arunachalam, Jothi,Moon, Dohyun,Veerappan, Anbazhagan. "Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane". . p. 32823 - 32831. Retrieved 2018/10/08.
• 3、 -. "CATIONIC LIPIDS". Page/Page column 27. . Retrieved 2009/05/28.