1-(4-Methoxyphenyl)-2-phenylaziridine

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)-2-phenylaziridine
• CAS No.: 64222-59-9
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• DSSTox Substance ID: DTXSID80572437
• Nikkaji Number: J2.163.332A
• Mol file: 64222-59-9.mol

Synonyms:1-(4-Methoxyphenyl)-2-phenylaziridine;64222-59-9;DTXSID80572437;1-(p-methoxyphenyl)-2-phenyl aziridine

Chemical Property of 1-(4-Methoxyphenyl)-2-phenylaziridine

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 225.115364102
• Heavy Atom Count: 17
• Complexity: 241

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N2CC2C3=CC=CC=C3

Technology Process of 1-(4-Methoxyphenyl)-2-phenylaziridine

There total 6 articles about 1-(4-Methoxyphenyl)-2-phenylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + p-methoxy-phenylazide (2101-87-3) → 1-(4'-methoxyphenyl)-2-phenylaziridine (64222-59-9)

Guidance literature:

With 5,10,15,20-tetraphenylporphyrinato ruthenium carbonyl; In benzene; for 6h; Schlenk technique; Reflux; Inert atmosphere;

DOI:10.1002/adsc.202000175

Reference yield: 51.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + p-methoxy-phenylazide (2101-87-3) → 1-(4'-methoxyphenyl)-2-phenylaziridine (64222-59-9) + 1-(4-methoxyphenyl)-5-phenyl-Δ2-1,2,3-triazoline (84817-33-4)

Guidance literature:

With choline chloride–urea; at 80 ℃; for 16h; Green chemistry;

DOI:10.1039/c8gc01797b

Reference yield: 34.0%

trimethylsulfoxonium iodide (1774-47-6) + [4-(benzylideneamino)phenyl]methanol (783-08-4) → 1-(4'-methoxyphenyl)-2-phenylaziridine (64222-59-9)

Guidance literature:

With potassium hydroxide; In solid; at 50 ℃; for 3h;

upstream raw materials:

trimethylsulfoxonium iodide

[4-(benzylideneamino)phenyl]methanol

Chloroiodomethane

4-methoxy-N-[(E)-phenylmethylidene]aniline

Downstream raw materials:

4-methoxy-N-(2-phenyl-2-(2-(pyridin-2-yl)phenyl)ethyl)aniline

Refernces

• 1、 Sebest, Filip,Casarrubios, Luis,Rzepa, Henry S.,White, Andrew J. P.,Díez-González, Silvia. "Thermal azide-Alkene cycloaddition reactions: straightforward multi-gram access to Δ2-1,2,3-Triazolines in deep eutectic solvents". supporting information. p. 4023 - 4035. Retrieved 2018/09/11.
• 2、 Fantauzzi, Simone,Gallo, Emma,Caselli, Alessandro,Piangiolino, Cristiana,Ragaini, Fabio,Cenini, Sergio. "The (porphyrin)ruthenium-catalyzed aziridination of olefins using aryl azides as nitrogen sources". . p. 6053 - 6059. Retrieved 2008/09/17.