2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID

Base Information

• Chemical Name: 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID
• CAS No.: 1991-79-3
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.088
• Hs Code.: 2922499990
• Mol file: 1991-79-3.mol

Synonyms:Alanine,3-(o-bromophenyl)- (7CI,8CI);2-Bromophenylalanine;

Chemical Property of 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 6.53E-06mmHg at 25°C
• Refractive Index: 1.608
• Boiling Point: 363.2 °C at 760 mmHg
• PKA: 2.16±0.10(Predicted)
• Flash Point: 173.4 °C
• PSA: 63.32000
• Density: 1.588 g/cm³
• LogP: 2.10380
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-3-(2-bromophenyl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-DL-phenylalanine is used as a reactant in the stereoselective preparation of isoquinoline-substituted secondary amines.

Technology Process of 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID

There total 4 articles about 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (acetylamino)<(2-bromophenyl)methyl>propanedioate (120667-45-0) → 2-amino-3-(2-bromophenyl)propanoic acid (1991-79-3)

Guidance literature:

With hydrogenchloride; In water; at 110 ℃; Microwave irradiation;

DOI:10.1021/acs.orglett.8b02791

Reference yield:

2-bromocinnamic acid (7345-79-1,20595-39-5,7499-56-1) → 2-amino-3-(2-bromophenyl)propanoic acid (1991-79-3)

Guidance literature:

With phenylalanine ammonia lyase from Anabaena variabilis; ammonium carbamate; at 30 ℃; for 22h; pH=9.9; Enzymatic reaction;

DOI:10.1002/cctc.201902128

Reference yield:

<(2-bromophenyl)methyl>propanedicarboxylic acid (58380-12-4) → 2-amino-3-(2-bromophenyl)propanoic acid (1991-79-3)

Guidance literature:

With tris-(2-chloro-ethyl)-amine; sulfuric acid; benzene;

upstream raw materials:

<(2-bromophenyl)methyl>propanedicarboxylic acid

diethyl (acetylamino)<(2-bromophenyl)methyl>propanedioate

2-bromocinnamic acid

Downstream raw materials:

(2R)-2-amino-3-(2-bromophenyl)propanoic acid

(S)-2-amino-3-(2-bromophenyl)propanoic acid

Refernces

• 1、 Liu, Xiangyuan,Liu, Yang,Chai, Guobi,Qiao, Baokun,Zhao, Xiaowei,Jiang, Zhiyong. "Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines". supporting information. p. 6298 - 6301. Retrieved 2018/10/09.
• 2、 -. "Lyase Enzymes, Nucleic Acids Encoding Them and Methods for Making and Using Them". . . Retrieved 2011/02/25.