Technology Process of Cefteram pivoxil
There total 5 articles about Cefteram pivoxil which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C21H25N9O7S2;
With
tetrapropylammonium iodide;
In
1,4-dioxane;
at 20 ℃;
for 2h;
iodomethyl pivaloate;
With
pyridine;
In
1,4-dioxane;
at -10 - 20 ℃;
for 1h;
With
t-butyldimethylsiyl triflate;
In
1,4-dioxane;
at 0 ℃;
for 0.25h;
- Guidance literature:
-
cefteram;
With
sodium methylate;
In
methanol; N,N-dimethyl-formamide;
at -20 ℃;
for 0.333333h;
iodomethyl pivaloate;
In
methanol; N,N-dimethyl-formamide;
at -20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / 0.33 h / 20 °C
1.2: 20 °C
2.1: dichloromethane / 2 h / 20 °C
2.2: 0.5 h / 20 °C
3.1: tetrapropylammonium iodide / 1,4-dioxane / 2 h / 20 °C
3.2: 1 h / -10 - 20 °C
3.3: 0.25 h / 0 °C
With
sulfuric acid; tetrapropylammonium iodide;
In
1,4-dioxane; dichloromethane;
