Technology Process of Acrivastine
There total 9 articles about Acrivastine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
silica gel; potassium hydroxide;
In
acetone;
at 35 - 45 ℃;
for 2h;
Reagent/catalyst;
Solvent;
Temperature;
Inert atmosphere;
Green chemistry;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 12.2 g / BuLi / hexane; diethyl ether / 3 h / -50 °C
2: 24.3 g / p-toluenesulfonic acid / toluene / 6 h / Heating
3: 2.5 g / BuLi / diethyl ether; hexane / 4 h / -50 °C
4: 1.) NaH, 2.) conc. HCl / 1.) DME, 2 h, 2.) ethanol, H2O, steam bath, 10 min
5: 1.) BuLi, 2.) NaOH / 1.) hexane, toluene, 75 deg C, 2 h, 2.) ethanol, steam bath, 10 min
With
hydrogenchloride; sodium hydroxide; n-butyllithium; sodium hydride; toluene-4-sulfonic acid;
In
diethyl ether; hexane; toluene;
DOI:10.1002/jps.2600731003
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 24.3 g / p-toluenesulfonic acid / toluene / 6 h / Heating
2: 2.5 g / BuLi / diethyl ether; hexane / 4 h / -50 °C
3: 1.) NaH, 2.) conc. HCl / 1.) DME, 2 h, 2.) ethanol, H2O, steam bath, 10 min
4: 1.) BuLi, 2.) NaOH / 1.) hexane, toluene, 75 deg C, 2 h, 2.) ethanol, steam bath, 10 min
With
hydrogenchloride; sodium hydroxide; n-butyllithium; sodium hydride; toluene-4-sulfonic acid;
In
diethyl ether; hexane; toluene;
DOI:10.1002/jps.2600731003
Xn,
Xi
