4,5,6,7-tetrahydro-3-methyl-3H-Imidazo[4,5-c]pyridine

Base Information

• Chemical Name: 4,5,6,7-tetrahydro-3-methyl-3H-Imidazo[4,5-c]pyridine
• CAS No.: 64403-25-4
• Molecular Formula: C7H11N3
• Molecular Weight: 137.18200
• Mol file: 64403-25-4.mol

Synonyms:

Chemical Property of 4,5,6,7-tetrahydro-3-methyl-3H-Imidazo[4,5-c]pyridine

Chemical Property:

• PSA: 29.85000
• LogP: 0.39460

Purity/Quality:

95+% ^*data from raw suppliers

3-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5,6,7-tetrahydro-3-methyl-3H-Imidazo[4,5-c]pyridine

There total 14 articles about 4,5,6,7-tetrahydro-3-methyl-3H-Imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyl 3-methyl-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate → 3-methyl-3,4,6,7-tetrahydro-5H-imidazo<4,5-c>pyridine (64403-25-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 16h; under 750.075 Torr; Inert atmosphere;

Reference yield:

1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester (1202800-68-7) + methyl iodide (74-88-4) → 1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine (87673-88-9) + 3-methyl-3,4,6,7-tetrahydro-5H-imidazo<4,5-c>pyridine (64403-25-4)

Guidance literature:

1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; at 0 - 26 ℃; for 0.166667h;

methyl iodide; In tetrahydrofuran; at 26 ℃; for 16h;

With methanol hydrochloride; In methanol; at 0 - 26 ℃; for 16h; Overall yield = 5.5 g;

Reference yield:

4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine dihydrochloride (62002-31-7,64403-23-2) → 3-methyl-3,4,6,7-tetrahydro-5H-imidazo<4,5-c>pyridine (64403-25-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 16 h / 20 °C

2: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; toluene / 12 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 750.08 Torr / Inert atmosphere

With tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; sodium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;

upstream raw materials:

N₁-methylhistamine

trimethyleneglycol

methyl bromide

benzyl 3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate

Refernces

• 1、 -. "DERIVATIVES OF N-[(1H-PYRAZOL-1-YL)ARYL]-1H-INDOLE OR 1H-INDAZOLE-3-CARBOXAMIDE, PREPARATION THEREOF AND APPLICATIONS THEREOF IN THERAPEUTICS". . . Retrieved 2012/11/08.
• 2、 Arcari,Bernardi,Cimaschi,Falconi,Luini,Scarponi. "Anti-ulcer and antisecretory activity of selected imidazopiperidines". . p. 1467 - 1471. Retrieved 2007/10/02.