Quin2-acetoxymethyl ester

Base Information

• Chemical Name: Quin2-acetoxymethyl ester
• CAS No.: 83104-85-2
• Molecular Formula: C38H43N3O18
• Molecular Weight: 829.7573
• European Community (EC) Number: 636-006-0
• UNII: 8EF0C5H59D
• DSSTox Substance ID: DTXSID10232173
• Nikkaji Number: J418.299E
• Wikidata: Q27270255
• Mol file: 83104-85-2.mol

Synonyms:quin-2 acetoxymethyl ester;Quin2-acetoxymethyl ester;Quin2-AM

Chemical Property of Quin2-acetoxymethyl ester

Chemical Property:

• Appearance/Colour: Yellow orange solid
• Vapor Pressure: 2.25E-30mmHg at 25°C
• Refractive Index: 1.576
• Boiling Point: 865.6 °C at 760 mmHg
• Flash Point: 477.3 °C
• PSA: 248.23000
• Density: 1.36 g/cm³
• LogP: 1.99880
• Storage Temp.: ?20°C
• Solubility.: DMSO: soluble
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 21
• Rotatable Bond Count: 30
• Exact Mass: 829.25416153
• Heavy Atom Count: 59
• Complexity: 1380

Purity/Quality:

98%min ^*data from raw suppliers

Quin2-AM ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCC2=NC3=C(C=C(C=C3C=C2)OC)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
• Description: Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 . As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM. It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.
• Uses: 2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester) Fluorescent probe for measurement of calcium in biological systems and for selected divalent cations. Quin 2-AM is a cell permeable fluorescent probe for Ca2+ that gives a large shift in the UV absorption spectrum and a 20-fold increase in fluorescence upon Ca2+ binding.