DL-2-HYDROXYDECANOIC ACID METHYL ESTER

Base Information

• Chemical Name: DL-2-HYDROXYDECANOIC ACID METHYL ESTER
• CAS No.: 71271-24-4
• Molecular Formula: C₁₁H₂₂O₃
• Molecular Weight: 202.294
• Mol file: 71271-24-4.mol

Synonyms:CP112994;Methyl 2-hydroxycaproate;Methyl 2-hydroxydecanoate;Methyl (±)-2-hydroxydecanoate;

Chemical Property of DL-2-HYDROXYDECANOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00377mmHg at 25°C
• Refractive Index: 1.444
• Boiling Point: 249 °C at 760 mmHg
• Flash Point: 103.2 °C
• PSA: 46.53000
• Density: 0.956 g/cm³
• LogP: 2.27090
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl (±)-2-hydroxydecanoate ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-2-HYDROXYDECANOIC ACID METHYL ESTER

There total 7 articles about DL-2-HYDROXYDECANOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl (E)-dec-2-enoate (7367-85-3) → 2-Hydroxycaprinsaeure-methylester (71271-24-4)

Guidance literature:

With phenylsilane; oxygen; bis(dipivaloylmethanato)manganese(II); In isopropyl alcohol; at 0 ℃; for 3h; under 760 Torr;

DOI:10.1246/cl.1990.1869

Reference yield: 75.0%

1,1,1-tris(methylthio)-2-decanol (124838-34-2) → 2-Hydroxycaprinsaeure-methylester (71271-24-4)

Guidance literature:

With mercury dichloride; mercury(II) oxide; In methanol; for 1h; Heating;

DOI:10.1246/bcsj.62.2013

Reference yield:

DL-2-hydroxydecanoic acid (5393-81-7,37639-46-6) → 2-Hydroxycaprinsaeure-methylester (71271-24-4)

Guidance literature:

With thionyl chloride; sodium hydrogencarbonate; In methanol; hexane;

upstream raw materials:

methanol

DL-2-hydroxydecanoic acid

methyl (E)-dec-2-enoate

1,1,1-tris(methylthio)-2-decanol

Downstream raw materials:

(+)-1,2-epoxy-decane

(R)-(+)-1,2-epoxydecane

(S)-2-Hydroxydecanoic acid

(R)-2-Hydroxydecansaeuremethylester

Refernces

• 1、 -. "Sulfur-based amides and bis-amides useful against skin disorders". . . Retrieved 2008/06/13.
• 2、 Inoki, Satoshi,Kato, Koji,Isayama, Shigeru,Mukaiyama, Teruaki. "A New and Facile Method for the Direct Preparation of α-Hydroxycarboxylic Acid Esters from α,β-Unsaturated Carboxylic Acid Esters with Molecular Oxygen and Phenylsilane Catalyzed by Bis(dipivaloylmethanato)manganese(II) Complex". . p. 1869 - 1872. Retrieved 2007/10/02.