Guanabenz

Base Information

• Chemical Name: Guanabenz
• CAS No.: 5051-62-7
• Molecular Formula: C8H8 Cl2 N4
• Molecular Weight: 231.084
• Hs Code.: 2928000090
• European Community (EC) Number: 225-750-8
• DSSTox Substance ID: DTXSID6045666
• Wikipedia: Guanabenz
• Wikidata: Q27164730
• NCI Thesaurus Code: C75647
• RXCUI: 140480
• ChEMBL ID: CHEMBL1313657
• Mol file: 5051-62-7.mol

Synonyms:Extraneal;icodextrin;Icodial

Chemical Property of Guanabenz

Chemical Property:

• Vapor Pressure: 8.63E-07mmHg at 25°C
• Melting Point: 227-229° (dec)
• Boiling Point: 405.7°Cat760mmHg
• PKA: pKa 8.1 (Uncertain)
• Flash Point: 199.1°C
• PSA: 74.26000
• Density: 1.49g/cm³
• LogP: 3.00130
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 230.0126017
• Heavy Atom Count: 14
• Complexity: 228

Purity/Quality:

99%, ^*data from raw suppliers

N-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-62
• Safety Statements: 22-36/37/39

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
• Recent ClinicalTrials: Oral Guanabenz for Multiple Sclerosis
• Recent EU Clinical Trials: A Study to Explore the Safety, Tolerability, Pharmacokinetic Profile, and Potential Efficacy of Guanabenz in Patients With Early Childhood Onset Vanishing White Matter (VWM)
• Description: Guanabenz is an α2-adrenergic agonist that exhibits pronounced hypotensive action, and that is associated with a reduction of overall peripheral vascular resistance, decline in frequency of cardiac contractions, and reduced cardiac output.
• Uses: alpha agonists It is used both independently and in combination with oral diuretics for treating various degrees of hypertension.
• Therapeutic Function: Antihypertensive

Technology Process of Guanabenz

There total 4 articles about Guanabenz which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

amidinohydrazine (amino guanidine) carbonate + 2,6-dichlorobenzaldehyde (83-38-5) → guanabenz (5051-62-7)

Guidance literature:

In ethanol;

Reference yield:

guanoxabenz (24047-25-4) → guanabenz (5051-62-7)

Guidance literature:

With cytochrome b5; mitochondrial amidoxime reducing component 1; NADH cytochrome b5 reductase; NADH; at 37 ℃; pH=6; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1021/jm8010417

Reference yield:

2,6-dichlorobenzaldehyde (83-38-5) + aminoguanidine (79-17-4) → guanabenz (5051-62-7)

Guidance literature:

With pyridine;

upstream raw materials:

2,6-dichlorobenzaldehyde

aminoguanidine

guanoxabenz

Refernces

• 1、 -. "Therapeutic agents". . . Retrieved 2008/06/13.