1,2-diacetoxy-4-propylbenzene

Base Information

• Chemical Name: 1,2-diacetoxy-4-propylbenzene
• CAS No.: 89266-70-6
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 236.268
• Mol file: 89266-70-6.mol

Synonyms:1,2-Benzenediol,4-propyl-, diacetate (9CI)

Chemical Property of 1,2-diacetoxy-4-propylbenzene

Chemical Property:

• Vapor Pressure: 0.00059mmHg at 25°C
• Boiling Point: 310.7°C at 760 mmHg
• Flash Point: 147.9°C
• PSA: 52.60000
• Density: 1.103g/cm³
• LogP: 2.48970

Purity/Quality:

99%min ^*data from raw suppliers

1,2-DIACETOXY-4-PROPYLBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-diacetoxy-4-propylbenzene

There total 6 articles about 1,2-diacetoxy-4-propylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.1%

4-allyl-1,2-phenylene diacetate (13620-82-1) + acetic anhydride (108-24-7) → 3-(3',4'-dihydroxyphenyl)-1-propanol (46118-02-9) + 4-[3-(acetyloxy)propyl]-1,2-phenylene diacetate (147000-27-9) + 4-propyl-1,2-phenyl diacetate (89266-70-6)

Guidance literature:

4-allyl-1,2-phenylene diacetate; With dimethylsulfide borane complex; In tetrahydrofuran; at -10 - 20 ℃; for 1.25h; Inert atmosphere;

With sodium perborate hexahydrate; In tetrahydrofuran; water; at 20 ℃; for 2h;

acetic anhydride; With dmap; In dichloromethane; at 20 ℃; for 2h;

DOI:10.3390/molecules16064632

Reference yield:

4-propylbenzene-1,2-diol (2525-02-2) → 4-propyl-1,2-phenyl diacetate (89266-70-6)

Guidance literature:

With acetic anhydride;

Reference yield:

1-allyl-3,4-methylenedioxybenzene (94-59-7) → 4-[3-(acetyloxy)propyl]-1,2-phenylene diacetate (147000-27-9) + 4-propyl-1,2-phenyl diacetate (89266-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / 1,4-dioxane / 24 h / 20 °C / Inert atmosphere

2.1: dmap / dichloromethane / 2 h / 20 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / -10 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C

3.3: 2 h / 20 °C

With dmap; dimethylsulfide borane complex; boron trifluoride diethyl etherate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.3390/molecules16064632

upstream raw materials:

dihydrosafrole

acetic anhydride

1-allyl-3,4-methylenedioxybenzene

isosafrole

Refernces

• 1、 -. "Catechol diacetate derivatives for inducing the production of nerve growth factor to treat degenerative diseases in the central nervous system". . . Retrieved 2008/06/13.