cis-4-aminomethylcyclohexane-1-carboxylic acid

Base Information

• Chemical Name: cis-4-aminomethylcyclohexane-1-carboxylic acid
• CAS No.: 1197-17-7
• Molecular Formula: C8H15 N O2
• Molecular Weight: 157.213
• Mol file: 1197-17-7.mol

Synonyms:cis-4-(Aminomethyl)-1-cyclohexanecarboxylicacid; cis-4-(Aminomethyl)cyclohexanecarboxylic acid; cis-AMCHA; cis-Tranexamicacid

Chemical Property of cis-4-aminomethylcyclohexane-1-carboxylic acid

Chemical Property:

• Vapor Pressure: 0.000268mmHg at 25°C
• Melting Point: 226-228°C
• Boiling Point: 300.2°C at 760 mmHg
• PKA: 4.79±0.25(Predicted)
• Flash Point: 135.4°C
• PSA: 63.32000
• Density: 1.095
• LogP: 1.53640
• Storage Temp.: Refrigerator
• Solubility.: Methanol (Slightly, Heated), Water (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-TranexamicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: cis-Tranexamic Acid (Tranexamic EP Impurity B) is antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic. Labelled cis-Tranexamic Acid Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic.

Technology Process of cis-4-aminomethylcyclohexane-1-carboxylic acid

There total 3 articles about cis-4-aminomethylcyclohexane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-aminomethyl-cyclohexanecarboxylic acid (1197-17-7,1197-18-8,701-54-2)

Guidance literature:

Reference yield:

3-aza-bicyclo[3.2.2]nonan-2-one (5592-68-7) → cis-4-aminomethyl-1-cyclohexanecarboxylic acid (1197-17-7)

Guidance literature:

With hydrogenchloride;

Reference yield:

→ cis-4-aminomethyl-1-cyclohexanecarboxylic acid (1197-17-7)

Guidance literature:

cis-Aminosaeure, TsOH, Wasser, Ionenaustauschharz;

upstream raw materials:

3-aza-bicyclo[3.2.2]nonan-2-one

Downstream raw materials:

4-({[3,4-dioxo-2-(1-pyrrolidinyl)-1-cyclobuten-1-yl]amino}methyl)cyclohexanecarboxylic acid

4-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]cyclohexanecarboxylic acid

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

benzyl trans-4-(aminomethyl)cyclohexanecarboxylate tosylate

Refernces

• 1、 Shimizu,Naito,Okano,Aoyagi. "Trans-4-aminomethylcyclohexanecarboxylic acid as a potent antiplasmin agent.". . p. 1012 - 1014. Retrieved 2007/10/06.