12-Hydroxydodecyl methacrylate

Base Information

• Chemical Name: 12-Hydroxydodecyl methacrylate
• CAS No.: 86282-42-0
• Molecular Formula: C16H30O3
• Molecular Weight: 270.412
• European Community (EC) Number: 289-218-7
• UNII: 2ACE4T7MME
• DSSTox Substance ID: DTXSID10235467
• Nikkaji Number: J333.948C
• Wikidata: Q83117359
• Mol file: 86282-42-0.mol

Synonyms:12-Hydroxydodecyl methacrylate;86282-42-0;12-hydroxydodecyl 2-methylprop-2-enoate;2ACE4T7MME;12-HydroxydodecylMethacrylate;EINECS 289-218-7;2-Propanoic acid, 2-methyl-, 12-hydroxydodecyl ester;starbld0011043;UNII-2ACE4T7MME;SCHEMBL63860;DTXSID10235467;12-HYDROXYDODECYL 2-METHYL-2-PROPENOATE;2-Methylpropenoic acid (12-hydroxydodecyl) ester

Chemical Property of 12-Hydroxydodecyl methacrylate

Chemical Property:

• Vapor Pressure: 8.08E-07mmHg at 25°C
• Boiling Point: 365.3°Cat760mmHg
• Flash Point: 138.8°C
• PSA: 46.53000
• Density: 0.937g/cm³
• LogP: 3.99900
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 14
• Exact Mass: 270.21949481
• Heavy Atom Count: 19
• Complexity: 236

Purity/Quality:

98%Min ^*data from raw suppliers

12-HydroxydodecylMethacrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C(=O)OCCCCCCCCCCCCO
• Uses: 12-Hydroxydodecyl Methacrylate can be used in the synthesis of IR-780-loaded phospholipid mimicking homopolymeric micelles for near IR imaging and photothermal therapy of pancreatic cancer. It can also be used to prepare good degradable adhesive compounds.

Technology Process of 12-Hydroxydodecyl methacrylate

There total 2 articles about 12-Hydroxydodecyl methacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1,12-dodecandiol (5675-51-4) + Methacryloyl chloride (920-46-7,26937-45-1) → 12-(methacryloyloxy)-1-dodecanol (86282-42-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 40 ℃; for 12h;

DOI:10.1021/ja406089c

Reference yield: 32.0%

poly(methacrylic acid) (79-41-4,25087-26-7,50867-57-7) + 1,12-dodecandiol (5675-51-4) → 12-(methacryloyloxy)-1-dodecanol (86282-42-0) + 1,12-Dodecanediol dimethacrylate (72829-09-5)

Guidance literature:

With toluene-4-sulfonic acid; 4-methoxy-phenol; In hexane; for 15h; Reflux;

upstream raw materials:

1,12-dodecandiol

Methacryloyl chloride

poly(methacrylic acid)

Refernces

• 1、 Seuring, Jan,Reiss, Philipp,Koert, Ulrich,Agarwal, Seema. "Synthesis, characterization and properties of a new polymerisable surfactant: 12-Methacryloyl dodecylphosphocholine". . p. 367 - 372. Retrieved 2010.
• 2、 Duan, Likun,Zhao, Yan. "Zwitterionic Molecularly Imprinted Cross-Linked Micelles for Alkaloid Recognition in Water". . p. 13457 - 13464. Retrieved 2019/11/16.