Daltroban

Base Information

• Chemical Name: Daltroban
• CAS No.: 79094-20-5
• Molecular Formula: C16H16ClNO4S
• Molecular Weight: 353.826
• Mol file: 79094-20-5.mol

Synonyms:BM 13505;Daltroban;SKF 96148;2-[4-[2-(4-Chlorophenyl)sulfonylaminoethyl]phenyl]acetic acid;

Chemical Property of Daltroban

Chemical Property:

• Vapor Pressure: 3.63E-13mmHg at 25°C
• Melting Point: 132.5-137.4 °C(lit.)
• Refractive Index: 1.609
• Boiling Point: 555.3 °C at 760 mmHg
• PKA: 4.33±0.10(Predicted)
• Flash Point: 289.6 °C
• PSA: 91.85000
• Density: 1.378 g/cm³
• LogP: 3.95980
• Solubility.: DMSO: 22 mg/mL, soluble

Purity/Quality:

98%min ^*data from raw suppliers

Daltroban >98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Immunosuppressant. Daltroban can be used as a2 receptor to target adipose-derived stem cell for treating ischemic diseases.

Technology Process of Daltroban

There total 2 articles about Daltroban which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzenesulfonyl chloride (98-60-2) → daltroban (79094-20-5,105218-03-9)

Guidance literature:

With sodium hydroxide; potassium carbonate; Multistep reaction; 1.) 80 deg C, 90 min, 2.) MeOH, RT, 2 h;

DOI:10.1016/0223-5234(91)90009-C

Reference yield:

→ daltroban (79094-20-5,105218-03-9)

Guidance literature:

Reference yield: 76.0%

daltroban (79094-20-5,105218-03-9) → 4-[2-(4-chlorophenylsulphonylamino)-ethyl]-phenylacetamide

Guidance literature:

With thionyl chloride; ammonia;

upstream raw materials:

4-chlorobenzenesulfonyl chloride

Downstream raw materials:

2-[4-[2-(4-chlorophenylsulphonylamino)-ethyl]-phenyl]-acetic acid piperidide

4-[2-(4-Chlorobenzenesulphonamido)-ethyl]-phenylacetic acid (1H-tetrazol-5-yl)-amide

Refernces

• 1、 -. "Sulphonamidophenylcarboxylic acid compounds and pharmaceutical compositions containing them". . . Retrieved 2008/06/13.