3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE

Base Information

• Chemical Name: 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
• CAS No.: 9040-59-9
• Molecular Weight: 0
• Mol file: 9040-59-9.mol

Synonyms:3'5'-Cyclic nucleotide phosphodiesterase 11; 3',5'-Cyclic nucleoside monophosphatephosphodiesterase; 3',5'-Cyclonucleotide phosphodiesterase; 3',5'-Nucleotidephosphodiesterase; CGMP-stimulated 3',5'-cyclic phosphodiesterase;CGMP-stimulated phosphodiesterase; Calcium-calmodulin-sensitive cyclicnucleotide phosphodiesterase; Calcium/calmodulin-dependent cyclic nucleotidephosphodiesterase; Calcium/calmodulin-dependent phosphodiesterase;Calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase;Calmodulin-stimulated cyclic nucleotide phosphodiesterase; Cyclic3',5'-mononucleotide phosphodiesterase; Cyclic 3',5'-nucleotide monophosphatephosphodiesterase; Cyclic 3',5'-nucleotide phosphodiesterase; Cyclic3',5'-phosphodiesterase; Cyclic nucleotide phosphodiesterase; Cyclic nucleotidephosphodiesterase 11A; Cyclic nucleotide phosphohydrolase; E.C. 3.1.4.17;Multifunctional phosphodiesterase; Nucleoside-3',5'-monophosphatephosphodiesterase; PDE1; PDE10; PDE11; PDE11A; PDE2; PDE2A; Phosphodiesterase1; Phosphodiesterase 10; Phosphodiesterase 10A; Phosphodiesterase 11;Phosphodiesterase 2; Phosphodiesterase 2A; Phosphodiesterase I;Phosphodiesterase II; Phosphodiesterase PDE11; Phosphodiesterase PDE11A;Phosphodiesterase PDE1A; Phosphodiesterase PDE2; Phosphodiesterase X;Phosphodiesterase type II

Chemical Property of 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE

Chemical Property:

• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain 15-30?units/mg protein (in the presence of 0.03 mM Ca2+ and a saturating level (10 units per ml) of calmodulin (P2277)), lyophilized powder ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: For use in calmodulin (P 0270) assay. Activity is reduced to <50% without calmodulin present. Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain has been used to assay the protein activator, calmodulin and in in vitro adenylate cyclase assay.
• Clinical Use: Phosphodiesterase-3 (PDE3) is an enzyme responsible for degradation of cAMP to AMP in platelets and blood vessels. Selective cAMP PDE3 inhibitors, such as dipyridamole and cilostazol , inhibit the degradation of cAMP, thereby increasing cellular concentration of cAMP and leading to inhibition of platelet aggregation and vasodilation.