2,5-Difluoroiodobenzene

Base Information

• Chemical Name: 2,5-Difluoroiodobenzene
• CAS No.: 2265-92-1
• Molecular Formula: C6H3 F2 I
• Molecular Weight: 239.991
• Hs Code.: 29039990
• Mol file: 2265-92-1.mol

Synonyms:1,4-Difluoro-2-iodobenzene;2,5-Difluoro-1-iodobenzene; 2,5-Difluoroiodobenzene; NSC 10262

Chemical Property of 2,5-Difluoroiodobenzene

Chemical Property:

• Vapor Pressure: 0.92mmHg at 25°C
• Refractive Index: n20/D 1.5600(lit.)
• Boiling Point: 178-179 °C(lit.)
• Flash Point: 185 °F
• PSA: 0.00000
• Density: 1.998 g/mL at 25 °C(lit.)
• LogP: 2.56940
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Difluoroiodobenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 68/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,5-Difluoroiodobenzene (1,4-Difluoro-2-iodobenzene) may be used in the synthesis of 3,6-difluoro-1,2-phenylenediboronic acid and 3,6-difluoro-2-iodobenzoic acid.

Technology Process of 2,5-Difluoroiodobenzene

There total 3 articles about 2,5-Difluoroiodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

para-difluorobenzene (540-36-3) → 1,4-difluoro-2-iodobenzene (2265-92-1)

Guidance literature:

With N-iodo-succinimide; boron trifluoride; at 0 - 5 ℃; for 0.25h;

Reference yield:

2,5-difluoroaniline (367-30-6) → 1,4-difluoro-2-iodobenzene (2265-92-1)

Guidance literature:

Multistep reaction; (i) NaNO₂, aq. HCl, (ii) aq. KI;

DOI:10.1139/v67-418

Reference yield:

→ 1,4-difluoro-2-iodobenzene (2265-92-1)

Guidance literature:

upstream raw materials:

2,5-difluoroaniline

para-difluorobenzene

Downstream raw materials:

1,4-difluoro-2,3-diiodobenzene

1,4-difluoro-9-fluorenone

2,5-difluorobenzonitrile

Refernces

• 1、 Prakash, G. K. Surya,Mathew, Thomas,Hoole, Dushyanthi,Esteves, Pierre M.,Wang, Qi,Rasul, Golam,Olah, George A.. "N-halosuccinimide/BF3-H2O, efficient electrophilic halogenating systems for aromatics". . p. 15770 - 15776. Retrieved 2007/10/03.
• 2、 Wang,Duan,Wiebe,Balzarini,De Clercq,Knaus. "Synthesis of 1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5- substituted-benzene thymidine mimics, some related α-anomers, and their evaluation as antiviral and anticancer agents". . p. 11 - 40. Retrieved 2007/10/03.