Imidazo[1,2-a]pyrimidine-3-carboxylic acid

Base Information

• Chemical Name: Imidazo[1,2-a]pyrimidine-3-carboxylic acid
• CAS No.: 64951-11-7
• Molecular Formula: C7H5N3O2
• Molecular Weight: 163.136
• Hs Code.: 2933990090
• European Community (EC) Number: 889-593-2
• DSSTox Substance ID: DTXSID60495498
• Wikidata: Q72482638
• Mol file: 64951-11-7.mol

Synonyms:Imidazo[1,2-a]pyrimidine-3-carboxylic acid;64951-11-7;MFCD09994697;IMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLICACID;SCHEMBL2814544;DTXSID60495498;AKOS005264504;CS-W022759;AC-28344;TS-00116;AM20120702;FT-0698761;EN300-98690;imidazo[1,2-a]-pyrimidine-3-carboxylic acid;W10235;W-60391;J-521507;Imidazo[1,2-a]pyrimidine-3-carboxylic acid, AldrichCPR;Z1198268370

Chemical Property of Imidazo[1,2-a]pyrimidine-3-carboxylic acid

Chemical Property:

• PSA: 67.49000
• LogP: 0.42750
• Storage Temp.: 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 163.038176411
• Heavy Atom Count: 12
• Complexity: 197

Purity/Quality:

98%min ^*data from raw suppliers

Imidazo[1,2-a]pyrimidine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C(=CN=C2N=C1)C(=O)O

Technology Process of Imidazo[1,2-a]pyrimidine-3-carboxylic acid

There total 2 articles about Imidazo[1,2-a]pyrimidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl imidazo<1,2-a>pyrimidine-3-carboxylate (64951-07-1) → imidazo[1,2-a]pyrimidine-3-carboxylic acid (64951-11-7)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃;

DOI:10.1016/j.ejmech.2021.113298

Reference yield:

→ imidazo[1,2-a]pyrimidine-3-carboxylic acid (64951-11-7)

Guidance literature:

Ester VI, HCl;

Reference yield: 48.0%

N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide (1315469-94-3) + imidazo[1,2-a]pyrimidine-3-carboxylic acid (64951-11-7) → N-(5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenyl)imidazo[1,2-a]pyrimidine-3-carboxamide

Guidance literature:

imidazo[1,2-a]pyrimidine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.166667h;

N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide; In N,N-dimethyl-formamide; at 60 ℃; for 15h;

DOI:10.1016/j.ejmech.2021.113298

upstream raw materials:

ethyl imidazo<1,2-a>pyrimidine-3-carboxylate

Refernces

• 1、 Abignente,Arena,de Caprariis,Parente. "Research on heterocyclic compounds. VII". . p. 735 - 746. Retrieved 2007/10/05.