Benzeneacetic acid, a-[[(phenylmethoxy)carbonyl]amino]-, 2-oxobutyl ester, (R)-

Base Information

• Chemical Name: Benzeneacetic acid, a-[[(phenylmethoxy)carbonyl]amino]-, 2-oxobutyl ester, (R)-
• CAS No.: 64975-72-0
• Molecular Formula: C20H21NO5
• Molecular Weight: 355.39
• Mol file: 64975-72-0.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-[[(phenylmethoxy)carbonyl]amino]-, 2-oxobutyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, a-[[(phenylmethoxy)carbonyl]amino]-, 2-oxobutyl ester, (R)-

There total 1 articles about Benzeneacetic acid, a-[[(phenylmethoxy)carbonyl]amino]-, 2-oxobutyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-chlorobutan-2-one (616-27-3) + (R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid potassium salt → (-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 2-oxo-butyl ester (64975-72-0)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1016/S0040-4020(99)00935-7

Reference yield:

(-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 2-oxo-butyl ester (64975-72-0) → (3R,5R)-5-ethyl-3-phenylmorpholin-2-one

Guidance literature:

Multi-step reaction with 3 steps

1: hydrobromic acid; acetic acid

2: potassium carbonate

3: borane-tetrahydrofuran complex / acetonitrile / 3 h / 20 °C

With borane-THF; hydrogen bromide; potassium carbonate; acetic acid; In acetonitrile; 1: Hydrolysis / 2: Cyclization / 3: Reduction;

DOI:10.1016/S0040-4020(99)00935-7

Reference yield:

(-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 2-oxo-butyl ester (64975-72-0) → (-)-(3R,5S)-5-ethyl-3-phenylmorpholin-2-one (157985-09-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrobromic acid; acetic acid

2: potassium carbonate

3: borane-tetrahydrofuran complex / acetonitrile / 3 h / 20 °C

With borane-THF; hydrogen bromide; potassium carbonate; acetic acid; In acetonitrile; 1: Hydrolysis / 2: Cyclization / 3: Reduction;

DOI:10.1016/S0040-4020(99)00935-7

upstream raw materials:

1-chlorobutan-2-one

Downstream raw materials:

5-ethyl-3R-phenyl-3,6-dihydro-[1,4]oxazin-2-one

(-)-(3R,5S)-5-ethyl-3-phenylmorpholin-2-one

Refernces