Methanone, (2-hydroxy-3-methoxyphenyl)phenyl-

Base Information

• Chemical Name: Methanone, (2-hydroxy-3-methoxyphenyl)phenyl-
• CAS No.: 65202-31-5
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Mol file: 65202-31-5.mol

Synonyms:

Chemical Property of Methanone, (2-hydroxy-3-methoxyphenyl)phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanone, (2-hydroxy-3-methoxyphenyl)phenyl-

There total 10 articles about Methanone, (2-hydroxy-3-methoxyphenyl)phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + phenylboronic acid (98-80-6) → (2-hydroxy-3-methoxyphenyl)(phenyl)methanone (65202-31-5)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 8h; Sealed tube;

DOI:10.1016/j.tet.2015.09.053

Reference yield: 70.0%

iodobenzene (591-50-4) + 3-methoxy-2-hydroxybenzaldehyde (148-53-8) → (2-hydroxy-3-methoxyphenyl)(phenyl)methanone (65202-31-5)

Guidance literature:

With sodium carbonate; lithium chloride; palladium dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 8h;

DOI:10.1246/cl.1996.823

Reference yield: 66.0%

2-benzenesulfonyloxy-3-methoxy-benzoic acid (196601-61-3) → (2-hydroxy-3-methoxyphenyl)(phenyl)methanone (65202-31-5)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In tetrahydrofuran; at 25 ℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/chem.201903816

upstream raw materials:

2-Hydroxy-3-methoxybenzonitrile

iodobenzene

3-methoxy-2-hydroxybenzaldehyde

2-(hydroxy-phenyl-methyl)-6-methoxy-phenol

Downstream raw materials:

7-methoxy-3-phenylbenzofuran

Refernces

• 1、 Ruzi, Rehanguli,Ma, Junyang,Yuan, Xiang-Ai,Wang, Wenliang,Wang, Shanshan,Zhang, Muliang,Dai, Jie,Xie, Jin,Zhu, Chengjian. "Deoxygenative Arylation of Carboxylic Acids by Aryl Migration". supporting information. p. 12724 - 12729. Retrieved 2019/11/05.
• 2、 Wang, Dahai,Cui, Sunliang. "Rh(III)-catalyzed aldehyde C-H bond functionalization of salicylaldehydes with arylboronic acids". . p. 8511 - 8516. Retrieved 2016/01/25.