1-Methyl-4-piperidyl acetate

Base Information

• Chemical Name: 1-Methyl-4-piperidyl acetate
• CAS No.: 6659-34-3
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.213
• Hs Code.: 2933399090
• European Community (EC) Number: 694-218-9
• UNII: SJO800UK0L
• DSSTox Substance ID: DTXSID90216754
• Nikkaji Number: J1.285.574E,J934.751H
• Wikidata: Q83093042
• ChEMBL ID: CHEMBL177847
• Mol file: 6659-34-3.mol

Synonyms:1-methyl-4-piperidyl acetate;1-methyl-4-piperidyl acetate, (14C)-labeled;1-methyl-4-piperidyl acetate, hydrochloride;M4P acetate

Chemical Property of 1-Methyl-4-piperidyl acetate

Chemical Property:

• Vapor Pressure: 0.553mmHg at 25°C
• Refractive Index: 1.471
• Boiling Point: 190 °C at 760 mmHg
• Flash Point: 68 °C
• PSA: 29.54000
• Density: 1.02 g/cm³
• LogP: 0.58160
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 157.110278721
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

98%min ^*data from raw suppliers

1-METHYL-4-PIPERIDYL ACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1CCN(CC1)C
• Recent EU Clinical Trials: Memory, Ageing, and the Cholinergic System

Technology Process of 1-Methyl-4-piperidyl acetate

There total 2 articles about 1-Methyl-4-piperidyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

N-methyl-4-hydroxypiperidine (106-52-5) + acetyl chloride (75-36-5) → 1-methyl-4-piperidinyl acetate (6659-34-3)

Guidance literature:

at 100 ℃; for 4h;

DOI:10.1248/cpb.46.231

Reference yield:

→ 1-methyl-4-piperidinyl acetate (6659-34-3)

Guidance literature:

DOI:10.1002/jps.2600590236 DOI:10.1139/v65-456

upstream raw materials:

N-methyl-4-hydroxypiperidine

acetyl chloride

Refernces

• 1、 Johnson,Tsakotellis,Degraw. "Effect of charge shielding by nonpolar groups on the partitioning of quaternized amines.". . p. 278 - 280. Retrieved 2007/10/04.