BN 227

Base Information

• Chemical Name: BN 227
• CAS No.: 72731-33-0
• Molecular Formula: C7H9 N O3
• Molecular Weight: 0
• Mol file: 72731-33-0.mol

Synonyms:AntibioticBN 227; Antibiotic G 1549; Cepabactin

Chemical Property of BN 227

Chemical Property:

• Vapor Pressure: 0.000127mmHg at 25°C
• Boiling Point: 298.5°C at 760 mmHg
• Flash Point: 134.3°C
• PSA: 51.46000
• Density: 1.29g/cm³
• LogP: 0.40260

Purity/Quality:

98% ^*data from raw suppliers

1-HYDROXY-5-METHOXY-6-METHYL-2(1H)-PYRIDINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BN 227

There total 10 articles about BN 227 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

6-chloro-3-methoxy-2-methylpyridine 1-oxide (129692-17-7) → 6-hydroxy-3-methoxy-2-methylpyridine 1-oxide (72731-33-0)

Guidance literature:

With potassium hydroxide; potassium carbonate; In toluene; benzyl alcohol; for 2h; Heating;

DOI:10.3987/COM-89-S75

Reference yield:

6-bromo-3-methoxy-2-methylpyridine-1-oxide (850882-88-1) → 6-hydroxy-3-methoxy-2-methylpyridine 1-oxide (72731-33-0)

Guidance literature:

With sodium hydroxide; at 150 ℃; for 0.333333h; under 9000.72 Torr; microwave irradiation;

DOI:10.1016/j.bmcl.2005.01.034

Reference yield:

2-methyl-3-pyridinol (1121-25-1,55780-69-3) → 6-hydroxy-3-methoxy-2-methylpyridine 1-oxide (72731-33-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 22 percent / Br₂; aq. NaOH / 20 °C

2: 91 percent / methanol; CH₂Cl₂ / 20 °C

3: 84 percent / mCPBA / CHCl₃ / 18 h / Heating

4: aq. NaOH / 0.33 h / 150 °C / 9000.72 Torr / microwave irradiation

With sodium hydroxide; bromine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2005.01.034

upstream raw materials:

6-chloro-3-methoxy-2-methylpyridine 1-oxide

6-bromo-3-methoxy-2-methylpyridine-1-oxide

2-methyl-3-pyridinol

2-bromo-5-hydroxyl-6-methylpyridine

Refernces

• 1、 Ohta, Akihiro,Takahashi, Nobuhiro,Shirokoma, Yasuko. "SYNTHESES OF A NATURALLY OCCURRING HYDROXAMIC ACID AND ITS ANALOGUES". . p. 875 - 884. Retrieved 2007/10/02.