Romifidine

Base Information

• Chemical Name: Romifidine
• CAS No.: 65896-16-4
• Molecular Formula: C9H9BrFN3
• Molecular Weight: 258.093
• Hs Code.: 2933290090
• European Community (EC) Number: 629-838-0
• UNII: 876351L05K
• DSSTox Substance ID: DTXSID40216103
• Nikkaji Number: J969.964C
• Wikipedia: Romifidine
• Wikidata: Q747850
• NCI Thesaurus Code: C74389
• RXCUI: 1091919
• Metabolomics Workbench ID: 152705
• ChEMBL ID: CHEMBL2105424
• Mol file: 65896-16-4.mol

Synonyms:N-(2-bromo-6-fluorophenyl)-4,5-dihydro-(1H)-imidazol-2-amine;romifidine;romifidine monohydrochloride;Sedivet;STH 2130

Chemical Property of Romifidine

Chemical Property:

• Vapor Pressure: 0.000944mmHg at 25°C
• Melting Point: 110 °C
• Refractive Index: 1.661
• Boiling Point: 303.2 °C at 760 mmHg
• PKA: 8.69±0.50(Predicted)
• Flash Point: 137.2 °C
• PSA: 36.42000
• Density: 1.72 g/cm³
• LogP: 1.79670
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 256.99639
• Heavy Atom Count: 14
• Complexity: 234

Purity/Quality:

99% ^*data from raw suppliers

Romifidine >95.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN=C(N1)NC2=C(C=CC=C2Br)F

Technology Process of Romifidine

There total 2 articles about Romifidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-[(2-bromo-6-fluoro-phenyl)-imino]-imidazolidine (65896-16-4)

Guidance literature:

Reference yield:

→ romifidine (65896-16-4)

Guidance literature:

Reference yield: 30.8%

romifidine (65896-16-4) + chloro(cyclopropyl)methane (5911-08-0) → (2-Bromo-6-fluoro-phenyl)-cyclopropylmethyl-(4,5-dihydro-1H-imidazol-2-yl)-amine (74544-78-8)

Guidance literature:

With sodium carbonate; In methanol; at 78 ℃; for 23h;

DOI:10.1021/jm00185a013

Downstream raw materials:

(2-Bromo-6-fluoro-phenyl)-cyclopropylmethyl-(4,5-dihydro-1H-imidazol-2-yl)-amine

Refernces

• 1、 -. "Feed additive for improving growth in agricultural animals". . . Retrieved 2008/06/13.