ETHYL 5-FLUORONICOTINATE

Base Information

• Chemical Name: ETHYL 5-FLUORONICOTINATE
• CAS No.: 22620-29-7
• Molecular Formula: C8H8FNO2
• Molecular Weight: 169.15
• Hs Code.: 29189900
• Mol file: 22620-29-7.mol

Synonyms:Nicotinicacid, 5-fluoro-, ethyl ester (8CI);Ethyl 5-fluoronicotinate;

Chemical Property of ETHYL 5-FLUORONICOTINATE

Chemical Property:

• Vapor Pressure: 0.159mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 214 °C at 760 mmHg
• PKA: 0.88±0.20(Predicted)
• Flash Point: 83.2 °C
• PSA: 39.19000
• Density: 1.197 g/cm³
• LogP: 1.39740
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 5-fluoronicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

Technology Process of ETHYL 5-FLUORONICOTINATE

There total 1 articles about ETHYL 5-FLUORONICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

→ Ethyl 5-fluoronicotinate (22620-29-7)

Guidance literature:

With 4-(difluoroiodo)toluene; boron trifluoride diethyl etherate; In chlorobenzene; at 45 ℃; for 36h;

Reference yield: 93.0%

Ethyl 5-fluoronicotinate (22620-29-7) → 5-fluoropyridine-3-carbohydrazide (701-40-6)

Guidance literature:

With hydrazine; In ethanol; at 20 ℃; for 5h;

Reference yield:

N-(5-bromo-6-methylpyridin-2-yl)-4-(tert-butyl)benzenesulfonamide + Ethyl 5-fluoronicotinate (22620-29-7) → N-(5-bromo-6-(2-(5-fluoropyridin-3-yl)-2-oxoethyl)pyridin-2-yl)-4-(tert-butyl)benzenesulfonamide

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

Downstream raw materials:

5-fluoropyridine-3-carbohydrazide

5-fluoropyridine-3-carboxaldehyde

C₁₃H₁₂FN₃O₃S

N-[3-(5-fluoro-pyridin-3-yl)acryloyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine

Refernces