Murraol

Base Information

• Chemical Name: Murraol
• CAS No.: 109741-38-0
• Molecular Formula: C15H16 O4
• Molecular Weight: 260.29
• Mol file: 109741-38-0.mol

Synonyms:2H-1-Benzopyran-2-one,8-(3-hydroxy-3-methyl-1-butenyl)-7-methoxy-, (E)-; 2H-1-Benzopyran-2-one,8-[(1E)-3-hydroxy-3-methyl-1-butenyl]-7-methoxy- (9CI); CM-c2; Murraol

Chemical Property of Murraol

Chemical Property:

• PSA: 59.67000
• LogP: 2.58570

Purity/Quality:

98%min ^*data from raw suppliers

Murraol ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Murraol

There total 9 articles about Murraol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C16H16O6 → murraol (109741-38-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 120 ℃; for 12h;

DOI:10.1021/acs.orglett.7b02290

Reference yield: 28.0%

7-methoxy-8-iodo-2H-chromen-2-one (65763-01-1) + 2-methyl-3-buten-2-ol (115-18-4) → (1'E)-8-(3'-hydroxy-3'-methylbut-1'-enyl)-7-methoxycoumarin (109741-38-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; copper(l) iodide; PdCl2; at 120 ℃; for 72h;

Reference yield:

osthole (484-12-8) → murraol (109741-38-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: AD-mix β; methanesulfonamide / tert-butyl alcohol; water / 12 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: toluene / 12 h / Reflux

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 12 h / 120 °C

With methanesulfonamide; AD-mix β; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; toluene; tert-butyl alcohol;

DOI:10.1021/acs.orglett.7b02290

upstream raw materials:

osthole

7-methoxy-8-(2',3'-dihydroxy-3'-methylbutyl)coumarin

7-methoxy-8-iodo-2H-chromen-2-one

2-methyl-3-buten-2-ol

Downstream raw materials:

8-Naphthoherniarin

Refernces

• 1、 Ito,Furukawa. "Two new coumarins from Murraya plants". . p. 819 - 820. Retrieved 1989.
• 2、 Su, Fangyi,Zhao, Zheng,Ma, Shuanggang,Wang, Rubing,Li, Yong,Liu, Yunbao,Li, Yuhuan,Li, Li,Qu, Jing,Yu, Shishan. "Cnidimonins A-C, Three Types of Hybrid Dimer from Cnidium monnieri: Structural Elucidation and Semisynthesis". . p. 4920 - 4923. Retrieved 2017/09/23.