4'-Methoxy-3-(trifluoromethyl)benzophenone

Base Information

• Chemical Name: 4'-Methoxy-3-(trifluoromethyl)benzophenone
• CAS No.: 845-05-6
• Molecular Formula: C15H11 F3 O2
• Molecular Weight: 280.246
• Hs Code.: 2914700090
• European Community (EC) Number: 212-681-3
• DSSTox Substance ID: DTXSID80233490
• Nikkaji Number: J195.117C
• Mol file: 845-05-6.mol

Synonyms:845-05-6;4'-Methoxy-3-(trifluoromethyl)benzophenone;4-Methoxy-3'-trifluoromethylbenzophenone;(4-methoxyphenyl)-[3-(trifluoromethyl)phenyl]methanone;EINECS 212-681-3;(4-Methoxyphenyl)(3-(trifluoromethyl)phenyl)methanone;(4-methoxyphenyl)[3-(trifluoromethyl)phenyl]methanone;MFCD13152564;Glucan;3-Trifluoromethylphenyl 4-methoxyphenyl ketone;9037-91-6;SCHEMBL7485522;DTXSID80233490;C15H11F3O2;AKOS009346422;C15-H11-F3-O2;3-Trifluoromethyl-4'-methoxybenzophenone;4-Methoxyphenyl[3-(trifluoromethyl)phenyl]methanone;Methanone, (4-methoxyphenyl)(3-(trifluoromethyl)phenyl)-

Chemical Property of 4'-Methoxy-3-(trifluoromethyl)benzophenone

Chemical Property:

• PSA: 26.30000
• LogP: 3.94500
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 280.07111408
• Heavy Atom Count: 20
• Complexity: 333

Purity/Quality:

97% ^*data from raw suppliers

4-Methoxy-3'-trifluoromethylbenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=CC(=CC=C2)C(F)(F)F

Technology Process of 4'-Methoxy-3-(trifluoromethyl)benzophenone

There total 5 articles about 4'-Methoxy-3-(trifluoromethyl)benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-(Trifluoromethyl)benzoyl chloride (2251-65-2) + methoxybenzene (100-66-3) → 3-Trifluoromethylphenyl 4-methoxyphenyl ketone (845-05-6)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In nitromethane; at 60 ℃; for 21h;

DOI:10.1016/j.bmc.2003.08.020

Reference yield: 26.0%

→ 3-Trifluoromethylphenyl 4-methoxyphenyl ketone (845-05-6)

Guidance literature:

Reference yield:

3-(Trifluoromethyl)benzoyl chloride (2251-65-2) → 3-Trifluoromethylphenyl 4-methoxyphenyl ketone (845-05-6) + petrol

Guidance literature:

aluminium chloride; In dichloromethane; methoxybenzene;

upstream raw materials:

3-bromo-1-trifluoromethylbenzene

sodium anisate

3-(Trifluoromethyl)benzoyl chloride

methoxybenzene

Downstream raw materials:

(4-hydroxyphenyl)(3-(trifluoromethyl)phenyl)methanone

(4-Methoxy-3-nitro-phenyl)-(3-trifluoromethyl-phenyl)-methanone

4'-Methoxy-3-trifluormethyl-benzhydrol

4',4''-Dimethoxy-3,3'-bis-trifluormethyl-benzpinakon

Refernces

• 1、 -. "Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same". . . Retrieved 2008/06/13.