N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea

Base Information

• Chemical Name: N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea
• CAS No.: 65647-48-5
• Molecular Formula: C9H8N4O2S
• Molecular Weight: 236.254
• Mol file: 65647-48-5.mol

Synonyms:Urea,N-(4-hydroxyphenyl)-N'-1,2,3-thiadiazol-5-yl;

Chemical Property of N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea

Chemical Property:

• Melting Point: >134°C (dec.)
• PKA: 10.07±0.26(Predicted)
• PSA: 111.38000
• Density: 1.638±0.06 g/cm3(Predicted)
• LogP: 1.24900
• Storage Temp.: Amber Vial, Refrigerator, Under inert atmosphere
• Solubility.: DMSO, Methanol (Sparingly)

Purity/Quality:

99% ^*data from raw suppliers

N-4-Hydroxyphenyl-N''-1,2,3-thiadiazol-5-ylurea ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-4-Hydroxyphenyl-N''-1,2,3-thiadiazol-5-ylurea is a substrate of cytokinin O-glucosyltransferase with position specificity related to receptor recognition. It is a metabolite of Thidiazuron (T344275) which is a non-purine containing urea derivative with cytokinin activity.

Technology Process of N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea

There total 2 articles about N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H10N4O2S → 4-hydroxythidiazuron (65647-48-5)

Guidance literature:

With boron tribromide; In dichloromethane; at -30 ℃; for 12h;

DOI:10.1021/acs.jafc.7b03522

Reference yield:

4-Methoxyphenyl isocyanate (5416-93-3) → 4-hydroxythidiazuron (65647-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 8 h / 80 °C

2: boron tribromide / dichloromethane / 12 h / -30 °C

With boron tribromide; In dichloromethane;

DOI:10.1021/acs.jafc.7b03522

upstream raw materials:

4-Methoxyphenyl isocyanate

Refernces