Dexfenfluramine hydrochloride

Base Information Edit

Chemical Name:Dexfenfluramine hydrochloride
CAS No.:3239-45-0
Molecular Formula:C₁₂H₁₆F₃N*ClH
Molecular Weight:267.722
Hs Code.:
European Community (EC) Number:221-806-0
UNII:PM28L0FHNP
DSSTox Substance ID:DTXSID7048871
Wikidata:Q27126873
NCI Thesaurus Code:C75111
ChEMBL ID:CHEMBL1887891
Mol file:3239-45-0.mol

Synonyms:Dexfenfluramine;Dexfenfluramine Hydrochloride;Hydrochloride, Dexfenfluramine;Redux

Suppliers and Price of Dexfenfluramine hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
Dexfenfluraminehydrochloride
10
$ 64.00

Sigma-Aldrich
(+)-Fenfluramine hydrochloride
100mg
$ 925.00

Sigma-Aldrich
(+)-Fenfluramine hydrochloride
25mg
$ 307.00

Biosynth Carbosynth
Dexfenfluramine hydrochloride
50 mg
$ 75.00

Biosynth Carbosynth
Dexfenfluramine hydrochloride
10 mg
$ 45.00

AK Scientific
Dexfenfluraminehydrochloride
50mg
$ 151.00

Total 21 raw suppliers

Chemical Property of Dexfenfluramine hydrochloride Edit

Chemical Property:

Appearance/Colour:White Crystalline Powder
Melting Point:159-163 °C
Boiling Point:243.1 °C at 760 mmHg
Flash Point:100.8 °C
PSA：12.03000
LogP:4.43880
Storage Temp.:Desiccate at RT
Solubility.:H2O: soluble10mg/mL
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:267.1001617
Heavy Atom Count:17
Complexity:203

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dexfenfluraminehydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 23/24/25
Safety Statements: 22-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCNC(C)CC1=CC(=CC=C1)C(F)(F)F.Cl
Isomeric SMILES:CCN[C@@H](C)CC1=CC(=CC=C1)C(F)(F)F.Cl
Recent ClinicalTrials:Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With Advanced Solid Tumors.
Description Redux, having been already launched in Europe, was marketed in Canada and the US for obesity. The (+)-isomer of fenfluramine is obtained by resolution using d-camphoric acid and ultimate conversion to the HCl salt. The levo-isomer has significant effects on dopaminerigic neurotransmission, while the dextro-isomer has a greater anorectic effect because it is more selective on serotonin as a 5-HT agonist with no dopaminergic or noradenergic activity. Redux inhibits the presynaptic release of serotonin, is a reuptake inhibitor, a 5-HT1B, receptor agonist, and a postsynaptic 5-HT2C receptor agonist . A dietary reduction in fat intake was thought to proceed via a CCK A-type receptor agonist activity. Due to the side effects of primary pulmonary hypertension, brain serotonin neurotoxicity and valvular heart disease, Redux was withdrawn world wide.
Uses Controlled substance. Anorexic

Technology Process of Dexfenfluramine hydrochloride

There total 10 articles about Dexfenfluramine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.52%