hydron;11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;chloride

Base Information

• Chemical Name: hydron;11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;chloride
• CAS No.: 29868-97-1
• Molecular Formula: C₁₉H₂₁N₅O₂*2ClH
• Molecular Weight: 424.33
• Mol file: 29868-97-1.mol

Synonyms:

Chemical Property of hydron;11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;chloride

Chemical Property:

• Appearance/Colour: white powder
• Melting Point: 248-250 °C
• Boiling Point: 541.7 °C at 760 mmHg
• Flash Point: 281.4 °C
• PSA: 74.23000
• Density: g/cm³
• LogP: 2.80740
• Storage Temp.: -20?C Freezer
• Sensitive.: Hygroscopic
• Solubility.: H2O: 50 mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 387.1462027
• Heavy Atom Count: 27
• Complexity: 534

Purity/Quality:

99% ^*data from raw suppliers

Pirenzepine, Dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4.[Cl-]
• Description: Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM). It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nmol/kg). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively). It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.
• Uses: An antiulcerative. Tricyclic gastric-acid inhibitor. Antiulcerative;M1 antagonist