Quinoline, 5-methyl-8-nitro-

Base Information

• Chemical Name: Quinoline, 5-methyl-8-nitro-
• CAS No.: 65745-69-9
• Molecular Formula: C10H8N2O2
• Molecular Weight: 188.186
• Mol file: 65745-69-9.mol

Synonyms:

Chemical Property of Quinoline, 5-methyl-8-nitro-

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 5-methyl-8-nitro-

There total 1 articles about Quinoline, 5-methyl-8-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(5-methyl-2-nitrophenyl)acetamide (7418-36-2) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 5-methyl-8-nitroquinoline (65745-69-9)

Guidance literature:

With boric acid; 2,4,6-Trinitrophenol; iron(II) sulfate; und Schwefelsaeure;

Reference yield: 93.0%

5-methyl-8-nitroquinoline (65745-69-9) → 5-methyl-8-aminoquinoline (85656-64-0)

Guidance literature:

With palladium on carbon; hydrogen; In ethyl acetate; Sealed tube;

DOI:10.1002/adsc.201600161

Reference yield:

5-methyl-8-nitroquinoline (65745-69-9) → 2,4,6-Trimethyl-benzenesulfonate1-amino-8-formylamino-5-methyl-quinolinium; (85656-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / 5percent palladium-charcoal / ethanol / 3 h / 1520 Torr / Ambient temperature

2: 72 percent / Heating

3: CH₂Cl₂ / 48 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

upstream raw materials:

N-(5-methyl-2-nitrophenyl)acetamide

glycerol

Downstream raw materials:

5-methyl-8-aminoquinoline

2,4,6-Trimethyl-benzenesulfonate1-amino-8-formylamino-5-methyl-quinolinium;