Technology Process of 1-(3-Chlorophenyl)-2-methylpiperazine
There total 6 articles about 1-(3-Chlorophenyl)-2-methylpiperazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / NH3, MeONa / methanol / 8 h
2: 73 percent / LiAlH4 / tetrahydrofuran; diethyl ether / Heating
3: 75 percent / Et3N / toluene / 6 h / Heating
4: 52 percent / 2 N HCl / 5 h / Heating
5: 1.) LiAlH4, 2.) aq. NaOH / 1.) Et2O, reflux, 3 h, 2.) Et2O, RT, 30 min
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; ammonia; sodium methylate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; toluene;
DOI:10.1021/jm970700n
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 87 percent / Et3N / 12 h / 100 °C
2: 89 percent / NH3, MeONa / methanol / 8 h
3: 73 percent / LiAlH4 / tetrahydrofuran; diethyl ether / Heating
4: 75 percent / Et3N / toluene / 6 h / Heating
5: 52 percent / 2 N HCl / 5 h / Heating
6: 1.) LiAlH4, 2.) aq. NaOH / 1.) Et2O, reflux, 3 h, 2.) Et2O, RT, 30 min
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; ammonia; sodium methylate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; toluene;
DOI:10.1021/jm970700n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 75 percent / Et3N / toluene / 6 h / Heating
2: 52 percent / 2 N HCl / 5 h / Heating
3: 1.) LiAlH4, 2.) aq. NaOH / 1.) Et2O, reflux, 3 h, 2.) Et2O, RT, 30 min
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; triethylamine;
In
toluene;
DOI:10.1021/jm970700n
