2-Amino-3-(1H-indol-3-yl)propanamide

Base Information

• Chemical Name: 2-Amino-3-(1H-indol-3-yl)propanamide
• CAS No.: 6720-02-1
• Molecular Formula: C11H13 N3 O
• Molecular Weight: 203.244
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20874200
• Nikkaji Number: J470.886E
• ChEMBL ID: CHEMBL1229086
• Mol file: 6720-02-1.mol

Synonyms:2-Amino-3-(1H-indol-3-yl)propanamide;6720-02-1;H-DL-Trp-NH2;H-DL-Trp-NH HCl;alpha-Amino-1H-indole-3-propanamide;tryptophan amide;d,l-tryptophanamide;L-Tryptophanamide, 9;SCHEMBL617181;CHEMBL1229086;SCHEMBL23300489;BDBM92688;DTXSID20874200;JLSKPBDKNIXMBS-UHFFFAOYSA-N;2-Amino-3-(3-indolyl)-Propanamide;MFCD03826622;AKOS005174524;Propanamide, 2-amino-3-(3-indolyl)-;AS-83245;alpha-Amino-(S)-1H-Indole-3-propanamide;2-Amino-3-(1H-indol-3-yl)propanamide #;FT-0697987;FT-0698792

Chemical Property of 2-Amino-3-(1H-indol-3-yl)propanamide

Chemical Property:

• PSA: 84.90000
• LogP: 1.92360
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 203.105862047
• Heavy Atom Count: 15
• Complexity: 244

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-3-(1H-indol-3-yl)propanamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)CC(C(=O)N)N

Technology Process of 2-Amino-3-(1H-indol-3-yl)propanamide

There total 8 articles about 2-Amino-3-(1H-indol-3-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tryptophanamide hydrochloride (67607-61-8) → DL-tryptophanamide (6720-02-1)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; 1,2-dichloro-ethane; for 0.25h; Product distribution / selectivity;

Reference yield:

DL-tryptophan methyl ester (7303-49-3) → DL-tryptophanamide (6720-02-1)

Guidance literature:

With methanol; ammonia;

DOI:10.1039/jr9530000285

Reference yield:

α-(hydroxyimino)-β-(indol-3-yl)propionic acid (60438-65-5) → DL-tryptophanamide (6720-02-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₃; water / 60 °C

2: HCl

3: methanol; NH₃

With hydrogenchloride; methanol; ammonia; water;

DOI:10.1039/jr9530000285

upstream raw materials:

DL-tryptophan methyl ester

L-tryptophanamide

α-(hydroxyimino)-β-(indol-3-yl)propionic acid

N^α-ethoxycarbonyl-DL-tryptophan-nitrile

Downstream raw materials:

(+/-)-2-(4-(dimethylamino)-4-phenylcyclohexylamino)-3-(1H-indol-3-yl)propanamide

Tryptamin

N-[2-Amino-3-(1H-indol-3-yl)-propyl]-N-(2-methoxy-benzyl)-acetamide

Refernces

• 1、 -. "Lavendamycin analogues and methods of synthesizing and using lavendamycin analogues". Page/Page column 6. . Retrieved 2010/10/20.