2-[(2,6-Dichlorophenyl)amino]benzeneacetyl chloride

Base Information

• Chemical Name: 2-[(2,6-Dichlorophenyl)amino]benzeneacetyl chloride
• CAS No.: 65950-49-4
• Molecular Formula: C14H10Cl3NO
• Molecular Weight: 314.599
• DSSTox Substance ID: DTXSID801224546
• Mol file: 65950-49-4.mol

Synonyms:2-[(2,6-Dichlorophenyl)amino]benzeneacetyl chloride;SCHEMBL11814221;DTXSID801224546;65950-49-4;2-[(2,6-dichlorophenyl)-amino]phenylacetyl chloride

Chemical Property of 2-[(2,6-Dichlorophenyl)amino]benzeneacetyl chloride

Chemical Property:

• XLogP3: 5.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 312.982797
• Heavy Atom Count: 19
• Complexity: 303

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CC(=O)Cl)NC2=C(C=CC=C2Cl)Cl

Technology Process of 2-[(2,6-Dichlorophenyl)amino]benzeneacetyl chloride

There total 1 articles about 2-[(2,6-Dichlorophenyl)amino]benzeneacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-(2,6-dichloroanilino)phenyl]acetic acid (15307-86-5) → 2-[2-(2,6-dichlorophenyl)aminophenyl]acetyl chloride (65950-49-4)

Guidance literature:

With thionyl chloride; In benzene;

Reference yield: 71.0%

2-[2-(2,6-dichlorophenyl)aminophenyl]acetyl chloride (65950-49-4) + 3,4,6-tri-O-acetyl-2-[(N-L-phenylalanyl)amino]-2-deoxy-β-D-glucopyranose → 3,4,6-tri-O-acetyl-2-[(N-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetyl)-L-phenylalanyl)amino]2-deoxy-β-D-glucopyranose

Guidance literature:

2-[2-(2,6-dichlorophenyl)aminophenyl]acetyl chloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 ℃; for 1h;

3,4,6-tri-O-acetyl-2-[(N-L-phenylalanyl)amino]-2-deoxy-β-D-glucopyranose; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 17h;

DOI:10.1039/c4ob01681e

Reference yield: 65.0%

2-[2-(2,6-dichlorophenyl)aminophenyl]acetyl chloride (65950-49-4) + homophthalic anhydride (703-59-3) → 3-[2'-(2'',6''-dichlorophenylamino)benzyl]isocoumarin

Guidance literature:

With triethylamine; N,N,N',N'-tetramethylguanidine; In acetonitrile; at 0 ℃; for 0.983333h;

DOI:10.1039/c4ra07223e

upstream raw materials:

[2-(2,6-dichloroanilino)phenyl]acetic acid

Downstream raw materials:

N-(4-cyano-1-oxo-2-phenyl-5-(pyrrolidin-1-yl)-1,2,4a,5,6,7,8,9-octahydropyrimido[1,6-a]azepin-3-yl)-2-[2-(2,6-dichlorophenyl)amino]phenylacetamide

2-[2-[(2,6-dichlorophenyl)amino]benzyl]-6-iodo-3,1-benzoxazin-4(H)-one

Refernces

• 1、 Biancalana, Lorenzo,Batchelor, Lucinda K.,De Palo, Alice,Zacchini, Stefano,Pampaloni, Guido,Dyson, Paul J.,Marchetti, Fabio. "A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds: Via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand". supporting information. p. 12001 - 12004. Retrieved 2017/09/25.
• 2、 Ashraf, Zaman,Saeed, Aamer,Nadeem, Humaira. "Design, synthesis and docking studies of some novel isocoumarin analogues as antimicrobial agents". . p. 53842 - 53853. Retrieved 2015/02/19.