2-Bromofuran

Base Information

• Chemical Name: 2-Bromofuran
• CAS No.: 584-12-3
• Molecular Formula: C4H3BrO
• Molecular Weight: 146.971
• Hs Code.: 2932190090
• European Community (EC) Number: 696-202-7
• DSSTox Substance ID: DTXSID50207108
• Nikkaji Number: J444H
• Wikidata: Q72456624
• Mol file: 584-12-3.mol

Synonyms:2-Bromofuran;584-12-3;Furan, 2-bromo-;2-Furyl bromide;alpha-Furyl bromide;bromofuran;2-bromo-furan;C4H3BrO;MFCD00216609;2-Bromofuran, stabilized with Copper (0.1%), Furan (0.5%) and Sodium Hydrogen Carbonate (0.4%);2-bromofurane;5-bromofuran;C4-H3-Br-O;SCHEMBL139257;DTXSID50207108;OYMCMWPHMPODNK-UHFFFAOYSA-N;AMY11096;BCP23391;2-Bromofuran (stabilized with copper);AKOS006229021;AB04890;AC-25233;TS-01910;AM20100423;B4555;FT-0611562;Q-103250;InChI=1/C4H3BrO/c5-4-2-1-3-6-4/h1-3;2-Bromofuran (stabilized with a layer of water and Calcium hydroxide)

Chemical Property of 2-Bromofuran

Chemical Property:

• Appearance/Colour: light yellow liquid
• Vapor Pressure: 32.8mmHg at 25°C
• Melting Point: 116 °C
• Refractive Index: 1.505
• Boiling Point: 106.6 °C at 760mmHg
• Flash Point: 18.3 °C
• PSA: 13.14000
• Density: 1.662 g/cm³
• LogP: 2.04210
• Sensitive.: Light Sensitive
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 145.93673
• Heavy Atom Count: 6
• Complexity: 46.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromofuran ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 11-36/37/38
• Safety Statements: 3/7-9-16-33-37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)Br

Technology Process of 2-Bromofuran

There total 13 articles about 2-Bromofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

furan (110-00-9) → 2-bromofuran (584-12-3)

Guidance literature:

With bromine; ethyllithium; In diethyl ether; 1.) 25 deg C, 1 h, 2.) -80 deg C;

Reference yield: 81.0%

5-bromo-furan-2-carboxylic acid (585-70-6) → 2-bromofuran (584-12-3)

Guidance literature:

With copper; In quinoline; Heating;

DOI:10.1021/ja00335a040

Reference yield: 23.0%

furan (110-00-9) + N,N-diethylaniline (91-66-7) → 2-bromofuran (584-12-3)

Guidance literature:

With bromine; In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

upstream raw materials:

1,4-dioxane

furan

bromocyane

5-bromo-furan-2-carboxylic acid

Downstream raw materials:

tris(2-furyl)arsane

Butadiyne

acetylene

2-phenylfuran

Refernces

• 1、 -. "Synthetic method of 3-aminomethyl tetrahydrofuran". Paragraph 0020-0022. . Retrieved 2018/09/08.
• 2、 Raheem, Mohammed-Abdul,Nagireddy, Jaipal R.,Durham, Robin,Tam, William. "Efficient procedure for the preparation of 2-bromofuran and its application in the synthesis of 2-arylfurans". experimental part. p. 2138 - 2146. Retrieved 2010/08/13.