1H-Isoindole

Base Information

• Chemical Name: 1H-Isoindole
• CAS No.: 270-69-9
• Molecular Formula: C8H7 N
• Molecular Weight: 117.15
• Mol file: 270-69-9.mol

Synonyms:2-Azaindene;Isoindolenine; Pseudoisoindole

Chemical Property of 1H-Isoindole

Chemical Property:

• Boiling Point: 217.8±20.0 °C(Predicted)
• PKA: 5.13±0.20(Predicted)
• PSA: 12.36000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 1.05470

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Isoindole

There total 2 articles about 1H-Isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl-methyl-amine (103-67-3) → isoindoline (270-69-9) + N-benzylidenemethylamine (25521-74-8)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 45 ℃; for 0.5h;

DOI:10.1002/anie.200352076

Reference yield:

benzyl-methyl-amine (103-67-3) → isoindoline (270-69-9) + N-benzylidenemethylamine (25521-74-8) + (E)-N-benzylidenebenzylamine (27845-50-7)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 25 ℃; for 0.166667h;

DOI:10.1021/ja0400382

Reference yield: 80.0%

isoindoline (270-69-9) → isoindoline (496-12-8)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 25 ℃; for 3h;

DOI:10.1021/jo00128a048

upstream raw materials:

benzyl-methyl-amine

Downstream raw materials:

isoindoline

Refernces

• 1、 Nicolaou,Mathison, Casey J. N.,Montagnon, Tamsyn. "New reactions of IBX: Oxidation of nitrogen- and sulfur-containing substrates to afford useful synthetic intermediates". . p. 4077 - 4082. Retrieved 2007/10/03.