Chemical Property of Anisodine
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Chemical Property:
- Boiling Point:495°Cat760mmHg
- Flash Point:253.2°C
- PSA：82.53000
- Density:1.39g/cm3
- LogP:-0.04000
- XLogP3:0.6
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:5
- Exact Mass:319.14197277
- Heavy Atom Count:23
- Complexity:462
- Purity/Quality:
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98%Min *data from raw suppliers
Anisodine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
- Canonical SMILES:CN1C2CC(CC1C3C2O3)OC(=O)C(CO)(C4=CC=CC=C4)O
- Isomeric SMILES:CN1[C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@@](CO)(C4=CC=CC=C4)O
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Description
Anisodine is isolated from the roots of the plant Solanaceae Anisodus tanguticus
(Maxim.) Pasch. (Scopolia tangutica Maxim.), which has a common name of
Zhang-Liu-Shen, growing at the plateau with an altitude of 1700–4300?m and richly
distributed in Tibet, Sichuan, Qinghai, Gansu, and other provinces in China.
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Physical properties
Appearance: white crystals or crystalline powder. Flash point: 253.2?°C. Melting
point: 126–128? °C (acetone-H2O), 190–192? °C (95% ethanol), and 197–200? °C
(absolute ethanol). MS m/e (%): 319(51), 154(14), 138(100), 96(5), 95(5), 94(36),
97(15), 96(5), 42(15), 137(25), and 119(23).
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Indications
Anisodine hydrobromide is recorded in the second volume of national standards for
chemical drugs of the People’s Republic of China. The formulation consists of
injection and tablet.
It is used clinically for treatment of migraine, retinal vascular spasm, ischemic
lesions, shrinking of the optic nerve, retina, and choroid, etc. It could improve the
functional recovery after acute paralysis induced by inflammation of the nervous
system and cerebrovascular disease, paralysis agitants, and carbon monoxideinduced toxic encephalopathy. It was also used for intravenous combined anesthesia, organophosphorus poisoning, bronchitis, asthma, and prevention and treatment
of seasickness.
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Clinical Use
In the past, anisodine was mainly used in the treatment of various diseases of the
central nervous system.
It had a certain therapeutic effect on patients with very low vision and deservesclinical application . When used for ischemic optic neuropathy treatment, anisodine significantly promoted the recovery of the visual field, with the effective rate as
high as 82.14% compared with conventional therapeutic regimen using corticosteroids combined with vasodilators, thrombolytic agents, vitamins, and antibiotics.
