D/L-LEUCINOL

Base Information

• Chemical Name: D/L-LEUCINOL
• CAS No.: 16369-17-8
• Molecular Formula: C6H15 N O
• Molecular Weight: 117.191
• Mol file: 16369-17-8.mol

Synonyms:Leucinol(6CI); (1-Hydroxymethyl-3-methylbutyl)amine; (?à)-Leucinol; 2-Amino-4-methyl-1-pentanol;2-Aminoisohexyl alcohol; DL-Leucinol; dl-Leucinol

Chemical Property of D/L-LEUCINOL

Chemical Property:

• Melting Point: 44°C
• Refractive Index: 1.4444 (estimate)
• Boiling Point: 198.6°Cat760mmHg
• Flash Point: 90.6°C
• PSA: 46.25000
• Density: 0.904g/cm³
• LogP: 1.05240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-43-36
• Safety Statements: 26-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D/L-LEUCINOL

There total 17 articles about D/L-LEUCINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ 2-amino-4-methyl-1-pentanol (7533-40-6,16369-17-8,53448-09-2,502-32-9,14438-11-0)

Guidance literature:

Reference yield: 84.0%

LEUCINE (328-39-2,21675-61-6,25248-98-0,70-45-1) → 2-amino-4-methylpentan-1-ol (16369-17-8,14438-11-0)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; for 15h; Heating;

DOI:10.1021/ac000604l

Reference yield: 83.0%

(R)-leucine methyl ester hydrochloride (5845-53-4,6322-53-8,7517-19-3) → 2-amino-4-methyl-1-pentanol (7533-40-6,16369-17-8,53448-09-2,502-32-9,14438-11-0)

Guidance literature:

With sodium tetrahydroborate; In ethanol; water; for 5.5h; Heating;

upstream raw materials:

D-leucine methyl ester

DL-leucine methyl ester

DL-leucine ethyl ester

DL-Leucyl-glycin

Downstream raw materials:

1-(bromomethyl)-3-methylbutylammonium bromide

C₁₇H₂₇NO₂

2-isobutyl-5-phenyl-1H-pyrrole

tert-butyl (1-hydroxy-4-methylpentan-2-yl)carbamate

Refernces

• 1、 Frey, Wolfgang,Giereth, Robin,Karnahl, Michael,Klo?, Marvin,Mengele, Alexander K.,Steffen, Andreas,Tschierlei, Stefanie. "Copper(I) Phosphinooxazoline Complexes: Impact of the Ligand Substitution and Steric Demand on the Electrochemical and Photophysical Properties". . p. 2675 - 2684. Retrieved 2020/03/04.
• 2、 Nishiwaki, Hisashi,Kuriyama, Mituhiro,Nagaoka, Hikaru,Kato, Akira,Yamauchi, Satoshi,Shuto, Yoshihiro,Akamatsu, Miki. "Synthesis of imidacloprid derivatives with a chiral alkylated imidazolidine ring and evaluation of their insecticidal activity and affinity to the nicotinic acetylcholine receptor". . p. 6305 - 6312,8. Retrieved 2012/12/11.