Bis(dimethylamino)chlorophosphine

Base Information

• Chemical Name: Bis(dimethylamino)chlorophosphine
• CAS No.: 3348-44-5
• Molecular Formula: C4H12ClN2P
• Molecular Weight: 154.579
• Hs Code.: 2929909090
• European Community (EC) Number: 222-100-5
• DSSTox Substance ID: DTXSID40187122
• Nikkaji Number: J100.185J
• Wikidata: Q72445130
• Mol file: 3348-44-5.mol

Synonyms:Bis(dimethylamino)chlorophosphine;3348-44-5;N-[chloro(dimethylamino)phosphanyl]-N-methylmethanamine;Chlorobis(dimethylamino)phosphine;Phosphorodiamidous chloride, tetramethyl-;1-chloro-N,N,N',N'-tetramethylphosphinediamine;EINECS 222-100-5;AI3-19432;P(NMe2)2Cl;C4H12ClN2P;((CH3)2N)2PCl;SCHEMBL3114456;Tetramethyldiaminochlorophosphine;C4-H12-Cl-N2-P;DTXSID40187122;bis(dimethylamino)phosphoruschloride;Bis(dimethylamino)phosphorus chloride;Phosphine, chlorobis(dimethylamino)-;MFCD00014862;Tetramethylphosphorodiamidous chloride;Bis(dimethylamino)chlorophosphine, 96%;FT-0693098;N,N,N',N'-Tetramethylphosphorodiamidous chloride

Chemical Property of Bis(dimethylamino)chlorophosphine

Chemical Property:

• Vapor Pressure: 4.17mmHg at 25°C
• Melting Point: -33 °C
• Refractive Index: 1.5010
• Boiling Point: 148.7 °C at 760 mmHg
• PKA: 1.17±0.70(Predicted)
• Flash Point: 43.7 °C
• PSA: 20.07000
• Density: 1.060 at 25 °C
• LogP: 1.57530
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 154.0426631
• Heavy Atom Count: 8
• Complexity: 59.1

Purity/Quality:

98% ^*data from raw suppliers

Bis(dimethylamino)chlorophosphine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 14-34
• Safety Statements: 23-26-36-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)P(N(C)C)Cl

Technology Process of Bis(dimethylamino)chlorophosphine

There total 13 articles about Bis(dimethylamino)chlorophosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Hexamethylphosphorous triamide (1608-26-0) → bis(N,N-dimethylamino)chlorophosphine (3348-44-5)

Guidance literature:

With phosphorus trichloride; cooling;

DOI:10.1002/ejoc.200500937

Reference yield: 82.0%

bis-(dimethylamino)methane (51-80-9) → bis(N,N-dimethylamino)chlorophosphine (3348-44-5)

Guidance literature:

With phosphorus trichloride;

Reference yield: 78.0%

N,N-Dimethyltrimethylsilylamine (2083-91-2) + N,N-dimethylaminodichlorophosphane (683-85-2) → bis(N,N-dimethylamino)chlorophosphine (3348-44-5)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/ejoc.201000213

upstream raw materials:

N,N-Dimethyltrimethylsilylamine

dimethyl amine

Hexamethylphosphorous triamide

bis-(dimethylamino)methane

Downstream raw materials:

1,3-Bis-benzenesulfonyl-N,N,N',N'-tetramethyl-[1,3,2,4]diazadiphosphetidine-2,4-diamine

p-C₆H₄(P(N(CH₃)2)2)2

tetra-N-methyl-2,3-diphenyl-11λ⁵-[1,3,2]oxazaphospholo[3',2':2,3][1,2,4,3]triazaphospholo[4,5-a]pyridine-11,11-diamine

bis(dimethylamino)phenyl phosphine

Refernces

• 1、 Maryanoff,B.E.,Hutchins,R.O.. "". . p. 3475 - 3480. Retrieved 1972.
• 2、 Al-Maydama, H. M. A.,Finch, Arthur,Gardner, P. J.,Head, A. J.. "The enthalpies of formation of (dimethylamino)dichlorophosphine, bis(dimethylamino)chlorophosphine, and tris(dimethylamino)phosphine". . p. 273 - 280. Retrieved 1995.
• 3、 Raytchev, Pascal Dimitrov,Martinez, Alexandre,Gornitzka, Heinz,Dutasta, Jean-Pierre. "Encaging the Verkade's superbases: Thermodynamic and kinetic consequences". supporting information; experimental part. p. 2157 - 2159. Retrieved 2011/04/23.