Levallorphan tartrate

Base Information

• Chemical Name: Levallorphan tartrate
• CAS No.: 71-82-9
• Molecular Formula: C19H25NO•C4H6O6
• Molecular Weight: 433.502
• European Community (EC) Number: 200-767-3
• UNII: U0VSF7HTN0
• DSSTox Substance ID: DTXSID601017345
• Wikidata: Q27290530
• NCI Thesaurus Code: C66005
• Mol file: 71-82-9.mol

Synonyms:Levallorphan tartrate;71-82-9;l-Levallorphan tartrate;Levallorphan hydrogen tartrate;Levallorphan (+)-tartrate salt;Levallorphan tartrate salt;Levallorphan tartrate [JAN];Tartrate de levallorphane [French];Tartrate de levallorphane;EINECS 200-767-3;UNII-U0VSF7HTN0;U0VSF7HTN0;17-Allylmorphinan-3-ol tartrate (1:1) (salt);71-82-9 (salt);C19H25NO.C4H6O6;Levallorphan tartrate [USP:JAN];2H-10,4a-Iminoethanophenanthren-6-ol, 11-allyl-1,3,4,9,10,10a-hexahydro-, tartrate;Morphinan-3-ol, 17-(2-propenyl)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt);Morphinan-3-ol, 17-allyl-, tartrate (1:1) (salt);17-(2-Propenyl)morphinan-3-ol tartrate;(4bR,8aR,9R)-11-allyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthren-3-ol (2R,3R)-2,3-dihydroxysuccinate;Levallorphan tartrate (JP17);SCHEMBL14973577;DTXSID601017345;LEVALLORPHAN TARTRATE [MI];(2R,3R)-2,3-dihydroxybutanedioic acid;(1R,9R,10R)-17-prop-2-enyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol;LEVALLORPHAN TARTRATE [MART.];AKOS040747060;LEVALLORPHAN TARTRATE [WHO-DD];LS-91867;LEVALLORPHAN TARTRATE [ORANGE BOOK];D02238;Levallorphan tartrate salt, >=98% (HPLC), powder;Q27290530;17-(2-Propenyl)-morphinan-3-ol (2R,3R)-2,3-dihydroxybutanedioate (salt);Morphinan-3-ol, 17-(2-propenyl)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) (salt)

Chemical Property of Levallorphan tartrate

Chemical Property:

• Vapor Pressure: 2.42E-18mmHg at 25°C
• Melting Point: 176-177°
• Boiling Point: 660.4°C at 760 mmHg
• PKA: pKa 4.5/6.9(H2O,t =25.0) (Uncertain)
• Flash Point: 353.2°C
• PSA: 23.47000
• LogP: 3.57450
• Solubility.: H2O: soluble
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 433.21005233
• Heavy Atom Count: 31
• Complexity: 542

Purity/Quality:

98%min ^*data from raw suppliers

Levallorphan tartrate salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C=CCN1CCC23CCCCC2C1CC4=C3C=C(C=C4)O.C(C(C(=O)O)O)(C(=O)O)O
• Isomeric SMILES: C=CCN1CC[C@]23CCCC[C@H]2[C@H]1CC4=C3C=C(C=C4)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
• Uses: Anti-narcotic agents Levallorphan tartrate is a narcotic-antagonist analgesic that counteracts the respiratory depression and analgesia caused by Morphine (Sulfate: M652290).

Technology Process of Levallorphan tartrate

There total 8 articles about Levallorphan tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

L-Tartaric acid (87-69-4,138508-61-9) + levallorphan (152-02-3) → levallorphan tartarate (71-82-9)

Guidance literature:

In acetone; at 45 - 50 ℃; for 2h;

Reference yield:

(+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline (51072-36-7,57849-23-7) → levallorphan tartarate (71-82-9)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen bromide / water / 17 h / 85 - 95 °C

2: L-Tartaric acid / ethanol / 6 h / 65 - 70 °C

3: potassium carbonate / acetone / 6 h

4: trifluorormethanesulfonic acid; acetic anhydride / 6 h / 35 - 40 °C / Inert atmosphere

5: acetone / 2 h / 45 - 50 °C

With L-Tartaric acid; trifluorormethanesulfonic acid; hydrogen bromide; acetic anhydride; potassium carbonate; In ethanol; water; acetone;

Reference yield:

(+)-1-(p-hydroxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline (74570-02-8,94006-09-4,125158-41-0) → levallorphan tartarate (71-82-9)

Guidance literature:

Multi-step reaction with 4 steps

1: L-Tartaric acid / ethanol / 6 h / 65 - 70 °C

2: potassium carbonate / acetone / 6 h

3: trifluorormethanesulfonic acid; acetic anhydride / 6 h / 35 - 40 °C / Inert atmosphere

4: acetone / 2 h / 45 - 50 °C

With L-Tartaric acid; trifluorormethanesulfonic acid; acetic anhydride; potassium carbonate; In ethanol; acetone;

upstream raw materials:

(+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline

(+)-1-(p-hydroxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline

L-Tartaric acid

levallorphan

Refernces