Fluorometholone acetate

Base Information

• Chemical Name: Fluorometholone acetate
• CAS No.: 3801-06-7
• Molecular Formula: C24H31FO5
• Molecular Weight: 418.506
• Hs Code.: 2937220000
• European Community (EC) Number: 223-270-3
• NSC Number: 47438
• UNII: 9I50C3I3OK
• DSSTox Substance ID: DTXSID20191424
• Nikkaji Number: J217.687D
• Wikipedia: Fluorometholone_acetate
• Wikidata: Q27105082
• NCI Thesaurus Code: C47535
• RXCUI: 221101
• Pharos Ligand ID: Y7HNTGXQ1ZFC
• ChEMBL ID: CHEMBL1201064
• Mol file: 3801-06-7.mol

Synonyms:FLUOROMETHOLONE ACETATE;3801-06-7;Eflone;Oxylone acetate;Flarex;Fluorometholone 17-acetate;9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 17-acetate;NSC 47438;NSC-47438;9I50C3I3OK;CHEBI:78354;U-17323;Fluorometholone acetate [USAN:USP];U-17,323;[(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate;6alpha-Methyl-9alpha-fluoro-17-acetoxy-21-deoxyprednisolone;AI3-52814;Fluorometholone acetate [USAN];NSC47438;EINECS 223-270-3;fluorometholone-acetate;U 17,323;UNII-9I50C3I3OK;SCHEMBL43184;U 17323;Fluorometholone acetate (USP);CHEMBL1201064;DTXSID20191424;HY-B1471;Pregna-1,4-diene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-6-methyl-, (6alpha,11beta)-;MFCD00866062;s4228;AKOS025401542;AC-2172;CCG-268873;FLUOROMETHOLONE ACETATE [MART.];FLUOROMETHOLONE ACETATE [VANDF];FLUOROMETHOLONE ACETATE [USP-RS];FLUOROMETHOLONE ACETATE [WHO-DD];FLUOROMETHOLONE 17-ACETATE [MI];NCGC00373228-02;BS-16978;NCI60_004118;CS-0013170;FLUOROMETHOLONE ACETATE [ORANGE BOOK];SW219098-1;D04221;D81740;FLUOROMETHOLONE ACETATE [USP MONOGRAPH];AB00641960_02;TOBRASONE COMPONENT FLUOROMETHOLONE ACETATE;Fluorometholone acetate 100 microg/mL in Acetonitrile;FLUOROMETHOLONE ACETATE COMPONENT OF TOBRASONE;Q27105082;Progesterone,17-dihydroxy-6.alpha.-methyl-,17-acetate;(6alpha,11beta)-17-(Acetyloxy)-9-fluoro-11-hydroxy-6-methylpregna-1,4-diene-3,20-dione;(6alpha,11beta)-9-fluoro-11-hydroxy-6-methyl-3,20-dioxopregna-1,4-dien-17-yl acetate;17-(Acetyloxy)-9-fluoro-11beta-hydroxy-6alpha-methylpregna-1,4-diene-3,20-dione;9-fluoro-11beta-hydroxy-6alpha-methyl-3,20-dioxopregna-1,4-dien-17-yl acetate;Pregna-1,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-6-methyl-, (6.alpha.,11.beta.)-;Pregna-1,20-dione, 9-fluoro-11.beta.,17-dihydroxy-6.alpha.-methyl-, 17-acetate;(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-17-hydroxy-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0?,?.0??,??]heptadeca-3,6-dien-14-yl acetate;Pregna-1,4-diene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-6-methyl-, (6.alpha.,11.beta.)-

Chemical Property of Fluorometholone acetate

Chemical Property:

• Vapor Pressure: 1.53E-13mmHg at 25°C
• Melting Point: 230-232°
• Refractive Index: 1.556
• Boiling Point: 532.1 °C at 760 mmHg
• PKA: 13.01±0.70(Predicted)
• Flash Point: 275.6 °C
• PSA: 80.67000
• Density: 1.24 g/cm³
• LogP: 3.49410
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 418.21555225
• Heavy Atom Count: 30
• Complexity: 892

Purity/Quality:

99% ^*data from raw suppliers

Fluorometholone acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1CC2C3CCC(C3(CC(C2(C4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)OC(=O)C
• Isomeric SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@]2([C@@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)OC(=O)C
• Uses: Fluorometholone Acetate is a glucocorticoid; anti-inflammatory.

Technology Process of Fluorometholone acetate

There total 1 articles about Fluorometholone acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 9-fluoro-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione 17-acetate (3801-06-7)

Guidance literature:

9α-Fluor-11β,17α-dihydroxy-6α-methyl-pregnadien-(1,4)-dion-(3,20), Eg., Acetanhydrid, p-Toluolsulfonsaeure;

DOI:10.1021/jo01079a612