N-(2-Aminoethyl)piperidine

Base Information

• Chemical Name: N-(2-Aminoethyl)piperidine
• CAS No.: 27578-60-5
• Molecular Formula: C7H16N2
• Molecular Weight: 128.217
• Hs Code.: 29333990
• European Community (EC) Number: 248-540-8
• NSC Number: 54993
• DSSTox Substance ID: DTXSID30181977
• Nikkaji Number: J309C
• Wikidata: Q72436895
• Mol file: 27578-60-5.mol

Synonyms:27578-60-5;N-(2-AMINOETHYL)PIPERIDINE;1-(2-Aminoethyl)piperidine;2-(piperidin-1-yl)ethanamine;1-Piperidineethanamine;2-(piperidin-1-yl)ethan-1-amine;2-piperidin-1-ylethanamine;2-Piperidinoethylamine;2-(1-Piperidinyl)ethanamine;(2-Piperidin-1-ylethyl)amine;N-Aminoethylpiperidine;2-piperidino-1-ethanamine;2-Piperidin-1-ylethylamine;2-(1-Piperidinyl)ethylamine;EINECS 248-540-8;AI3-11524;NSC54993;MFCD00006516;2-aminoethylpiperidine;2-piperidinoethanamine;1-Piperidineethylamine;2-piperidinylethylamine;N-(aminoethyl)piperidine;1-(aminoethyl)piperidine;N-(aminoethyl)-piperidine;2-piperdin-1-ylethylamine;EC-000.1345;1-(2-aminoethyl)piperdine;2-(1-Piperidino)ethylamine;2-Piperidine-1-ylethanamine;2-(1-piperidyl) ethylamine;SCHEMBL42457;2-Piperidin-1-yl-ethylamine;1-(2-aminoethyl)-piperidine;2-piperidine-1-yl-ethylamine;1-(2-Aminoethyl) piperidine;2-(piperidin-I-yl)ethanamine;(2-piperidin-1-yl)ethylamine;2-(piperidin-1-yl)ethylamine;2-piperidin-1-yl-ethyl amine;2-(1-Piperidinyl)ethanamine #;CJNRGSHEMCMUOE-UHFFFAOYSA-;Piperidine, 1-(2-aminoethyl)-;AMY5277;DTXSID30181977;HMS1767C03;1-(2-Aminoethyl)piperidine, 98%;STR03551;NSC 54993;NSC-54993;STK937194;AKOS000201110;CS-W007776;SB12747;A1026;A5331;BB 0259608;FT-0613366;FT-0629106;EN300-21749;P10019;J-016815;F2187-2168

Chemical Property of N-(2-Aminoethyl)piperidine

Chemical Property:

• Appearance/Colour: clear colourless to yellow liquid
• Vapor Pressure: 1.079mmHg at 25°C
• Melting Point: 67-70 °C(Solv: ligroine (8032-32-4); dichloromethane (75-09-2))
• Refractive Index: n20/D 1.473(lit.)
• Boiling Point: 185.999 °C at 760 mmHg
• PKA: pK1: 6.38;pK2: 9.89 (30°C)
• Flash Point: 57.778 °C
• PSA: 29.26000
• Density: 0.924 g/cm³
• LogP: 1.06920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Water Solubility.: Partly miscible in water.
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 128.131348519
• Heavy Atom Count: 9
• Complexity: 67.3

Purity/Quality:

98% ^*data from raw suppliers

N-(2-Aminoethyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, Xi
• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCN(CC1)CCN
• Uses: 1-(2-Aminoethyl)piperidine is used in modification of vinylbenzyl chloride/divinylbenzene gel copolymer bead and in the synthesis of linkage isomers trans-bis[1-(2-aminoethyl)piperidine]dinitronickel and trans-bis[1-(2-aminoethyl)-piperidine]dinitritonickel. It is also used as a reactant for synthesis of: analogs of anticancer agents, inhibitor of botulinum neurotoxin serotype A light chain, P. falciparum malaria, and Ebola filovirus, cannabinoid CB1 receptor antagonists, small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells, potent and selective 5-HT6 antagonists and N-mustards as anticancer agents. 1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.

Technology Process of N-(2-Aminoethyl)piperidine

There total 22 articles about N-(2-Aminoethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2-(piperidin-1-yl)ethyl)carbamic acid tert-butyl ester (777090-42-3) → 1-(2-aminoethyl)piperidine (27578-60-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 14h;

Reference yield: 93.44%

2-(piperidin-4-yl)ethyl chloride (1932-03-2) → 1-(2-aminoethyl)piperidine (27578-60-5)

Guidance literature:

With ammonia; In methanol; at 25 ℃; for 12h;

Reference yield: 81.0%

3-(piperidin-1-yl)propanehydrazide (29800-31-5) → 1-(2-aminoethyl)piperidine (27578-60-5)

Guidance literature:

With hydrogenchloride; sodium nitrate; In water; at 0 - 80 ℃; for 7h;

upstream raw materials:

ethyleneimine

piperidine

2-(2-bromoethyl)isoindoline-1,3-dione

sulfuric acid mono-(2-amino-ethyl ester)

Downstream raw materials:

diphenyl-acetic acid-(2-piperidino-ethylamide)

(2S,3S)-2-(4-bromobenzyloxy)-3,4-epoxy-N-(2-piperidin-1-yl-ethyl)-butyramide

(2R,3S)-2-(4-bromobenzyloxy)-3,4-epoxy-N-(2-piperidin-1-yl-ethyl)-butyramide

(2S,3R)-2-(4-bromobenzyloxy)-3,4-epoxy-N-(2-piperidin-1-yl-ethyl)-butyramide

Refernces

• 1、 Tazarki, Helmi,Zeinyeh, Wael,Esvan, Yannick J.,Knapp, Stefan,Chatterjee, Deep,Schr?der, Martin,Joerger, Andreas C.,Khiari, Jameleddine,Josselin, Béatrice,Baratte, Blandine,Bach, Stéphane,Ruchaud, Sandrine,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale. "New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis". . p. 304 - 317. Retrieved 2019/02/07.
• 2、 -. "C-3 NOVEL TRITERPENONE WITH C-28 UREA DERIVATIVES AS HIV INHIBITORS". Page/Page column 41. . Retrieved 2017/05/02.