Ethanethioic acid, [(4-chlorophenyl)amino]oxo-, hydrazide

Base Information

• Chemical Name: Ethanethioic acid, [(4-chlorophenyl)amino]oxo-, hydrazide
• CAS No.: 669065-21-8
• Molecular Formula: C8H8ClN3OS
• Molecular Weight: 229.69
• Mol file: 669065-21-8.mol

Synonyms:

Chemical Property of Ethanethioic acid, [(4-chlorophenyl)amino]oxo-, hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanethioic acid, [(4-chlorophenyl)amino]oxo-, hydrazide

There total 2 articles about Ethanethioic acid, [(4-chlorophenyl)amino]oxo-, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(4-chloro-phenyl)-2-morpholin-4-yl-2-thioxo-acetamide (220897-82-5) → N(1)-(4-chlorophenyl)-2-hydrazino-2-thioxoacetamide (669065-21-8)

Guidance literature:

With hydrazine hydrate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/acs.orglett.5b01718

Reference yield:

2-chloro-N-(4-chlorophenyl)acetamide (3289-75-6) → N(1)-(4-chlorophenyl)-2-hydrazino-2-thioxoacetamide (669065-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur / dimethylformamide / 1 h / 20 °C

2: 84.5 percent / hydrazine hydrate / dimethylformamide / 20 °C

With sulfur; hydrazine hydrate; In N,N-dimethyl-formamide;

DOI:10.1023/B:RUJO.0000010181.01921.77

Reference yield: 92.0%

3β-acetoxy-17-chloro-16-formylandrost-5,16-diene (1865-56-1) + N(1)-(4-chlorophenyl)-2-hydrazino-2-thioxoacetamide (669065-21-8) → C28H32ClN3O2

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; Reflux;

DOI:10.1039/c6ra06881b

upstream raw materials:

N-(4-chloro-phenyl)-2-morpholin-4-yl-2-thioxo-acetamide

2-chloro-N-(4-chlorophenyl)acetamide

Downstream raw materials:

N-(4-chloro-phenyl)-2-(4-oxo-2-thioxo-thiazolidin-3-ylamino)-2-thioxo-acetamide

3β-acetoxy-17-chloro-16-{2-[2-(4-chlorophenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}formylandrosta-5,16-diene

Refernces

• 1、 Chudinov, Mikhail V.,Lukin, Alexey Yu,Vedekhina, Tatiana S.. "5-nitrofuran-2-yl thiohydrazones as double antibacterial agents synthesis and in vitro evaluation". . p. 356 - 361. Retrieved 2020/04/17.
• 2、 Komkov, Alexander V.,Komendantova, Anna S.,Menchikov, Leonid G.,Chernoburova, Elena I.,Volkova, Yulia A.,Zavarzin, Igor V.. "A Straightforward Approach toward Multifunctionalized Pyridazines via Imination/Electrocyclization". supporting information. p. 3734 - 3737. Retrieved 2015/08/18.