10-formyldihydrofolate

Base Information

• Chemical Name: 10-formyldihydrofolate
• CAS No.: 28459-40-7
• Molecular Formula: C20H21 N7 O7
• Molecular Weight: 471.42
• Mol file: 28459-40-7.mol

Synonyms:Glutamicacid, N-[p-[N-[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-(8CI); L-Glutamic acid,N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-(9CI); 10-Formyl-7,8-dihydrofolic acid; N-Formyl-7,8-dihydrofolic acid

Chemical Property of 10-formyldihydrofolate

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 3.38±0.10(Predicted)
• Flash Point: °C
• PSA: 221.16000
• Density: 1.67g/cm³
• LogP: 0.50370

Purity/Quality:

99% ^*data from raw suppliers

10-Formyl-7,8-dihydroFolicAcid(>85%)DisodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 10-Formyl-7,8-dihydrofolic acid is a novel folate found in methotrexate-treated cells. 10-Formyldihydrofolate (H2folate) has not been found as a component of intracellular folates in normal tissues but has been identified in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells.

Technology Process of 10-formyldihydrofolate

There total 3 articles about 10-formyldihydrofolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-(10-formyl-7,8-dihydro-pteroyl)-L-glutamic acid (28459-40-7)

Guidance literature:

With sodium hydroxide; oxygen;

DOI:10.1021/ja01151a028

Reference yield:

tetrahydrofolic acid (135-16-0) + N-formimidoyl-L-glutamic acid (816-90-0) → N-(10-formyl-7,8-dihydro-pteroyl)-L-glutamic acid (28459-40-7)

Guidance literature:

With enzyme-substance from mammal liver;

DOI:10.1016/0003-9861(56)90033-9

Reference yield:

→ N-(10-formyl-7,8-dihydro-pteroyl)-L-glutamic acid (28459-40-7)

Guidance literature:

With coenzyme-A; enzyme-substance from clostridium sticklandii; 2-oxo-propionic acid;

DOI:10.1016/0006-3002(58)90484-0

upstream raw materials:

tetrahydrofolic acid

N-formimidoyl-L-glutamic acid

Refernces

• 1、 MILLER,WAELSCH. "The transfer of the formimino group of formamidinoglutaric acid to tetrahydrofolic acid.". . p. 263 - 266. Retrieved 2007/11/09.