N-[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]acetamide

Base Information

• Chemical Name: N-[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]acetamide
• CAS No.: 7354-88-3
• Molecular Formula: C11H9 N3 O5 S2
• Molecular Weight: 327.342
• European Community (EC) Number: 654-369-3
• NSC Number: 72989
• DSSTox Substance ID: DTXSID80994312
• Wikidata: Q82985211
• Mol file: 7354-88-3.mol

Synonyms:7354-88-3;N-{5-[(4-nitrophenyl)sulfonyl]-1,3-thiazol-2-yl}acetamide;NSC72989;N-[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]acetamide;Cambridge id 5754469;Oprea1_334873;Oprea1_779485;N-(5-((4-nitrophenyl)sulfonyl)thiazol-2-yl)acetamide;DTXSID80994312;NSC-72989;STK873822;AKOS002271078;EU-0036747;AB00095857-01;SR-01000419713;SR-01000419713-1;Z30208095;2-ACETAMIDO-5-(4-NITROPHENYLSULFONYL)-THIAZOLE;F0359-0099;N-[5-(4-Nitrobenzene-1-sulfonyl)-1,3-thiazol-2-yl]ethanimidic acid

Chemical Property of N-[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]acetamide

Chemical Property:

• PSA: 158.57000
• Density: 1.593g/cm³
• LogP: 3.51950
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 326.99836274
• Heavy Atom Count: 21
• Complexity: 505

Purity/Quality:

99%min ^*data from raw suppliers

2-ACETAMIDO-5-(4-NITROPHENYLSULFONYL)-THIAZOLE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=NC=C(S1)S(=O)(=O)C2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of N-[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]acetamide

There total 6 articles about N-[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-nitro-benzenesulfonyl)-acetaldehyde diethylacetal (775342-82-0) → N-[5-(4-nitro-benzenesulfonyl)-thiazol-2-yl]-acetamide (7354-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine / anschliessend Erhitzen mit wss. Thioharnstoff

With bromine; acetic acid;

Reference yield:

1-acetoxy-1-chloro-2-(4-nitro-benzenesulfonyl)-ethane (685530-24-9) → N-[5-(4-nitro-benzenesulfonyl)-thiazol-2-yl]-acetamide (7354-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrochloric acid

2: acetic acid; bromine / anschliessend Erhitzen mit wss. Thioharnstoff

With hydrogenchloride; bromine; acetic acid;

Reference yield:

1-[(2,2-diethoxyethyl)sulfanyl]-4-nitrobenzene (81146-79-4) → N-[5-(4-nitro-benzenesulfonyl)-thiazol-2-yl]-acetamide (7354-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: KMnO₄; aqueous acetic acid

2: acetic acid; bromine / anschliessend Erhitzen mit wss. Thioharnstoff

With potassium permanganate; bromine; acetic acid;

upstream raw materials:

5-[(4-nitrophenyl)sulfonyl]-1,3-thiazol-2-amine

acetic anhydride

1-[(2,2-diethoxyethyl)sulfanyl]-4-nitrobenzene

(4-nitro-benzenesulfonyl)-acetaldehyde diethylacetal

Downstream raw materials:

5-[(4-nitrophenyl)sulfonyl]-1,3-thiazol-2-amine

thiazosulfone