1-Ethoxy-2-methoxyethane

Base Information

• Chemical Name: 1-Ethoxy-2-methoxyethane
• CAS No.: 5137-45-1
• Molecular Formula: C5H12 O2
• Molecular Weight: 104.149
• Hs Code.: 2909199090
• European Community (EC) Number: 225-893-6
• DSSTox Substance ID: DTXSID40964490
• Nikkaji Number: J203.329A
• Wikidata: Q82946487
• Mol file: 5137-45-1.mol

Synonyms:1-Ethoxy-2-methoxyethane;2,5-Dioxaheptane;5137-45-1;ETHYLENE GLYCOL ETHYL METHYL ETHER;Ethane, 1-ethoxy-2-methoxy-;500005-27-6;1-ethoxy-2-methoxy-ethane;SCHEMBL12228;SCHEMBL7415141;DTXSID40964490;EINECS 225-893-6;MFCD00048580;FT-0635555

Chemical Property of 1-Ethoxy-2-methoxyethane

Chemical Property:

• Vapor Pressure: 0.0748mmHg at 25°C
• Refractive Index: 1.3870
• Boiling Point: 102°Cat760mmHg
• Flash Point: 4.9°C
• PSA: 18.46000
• Density: 0.841g/cm³
• LogP: 0.66930
• Water Solubility.: Fully miscible in water.
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 104.083729621
• Heavy Atom Count: 7
• Complexity: 29.3

Purity/Quality:

98%Min ^*data from raw suppliers

ETHYLENE GLYCOL ETHYL METHYL ETHER 97.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOCCOC
• Uses: It is employed in the reaction of metal salts of thymine and uracil with tetra-acetyl-α-glucopyranosyl bromide.

Technology Process of 1-Ethoxy-2-methoxyethane

There total 7 articles about 1-Ethoxy-2-methoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

trimethyl phosphite (512-56-1) + 2-ethoxy-ethanol (110-80-5) → 1-methoxy-2-ethoxyethane (5137-45-1)

Guidance literature:

With PPA; at 180 - 190 ℃; for 2h;

DOI:10.3891/acta.chem.scand.52-1223

Reference yield:

diethylene glycol dimethyl ether (111-96-6) → methanol (67-56-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,2-dimethoxyethane (110-71-4) + methoxyethene (107-25-5,9003-09-2) + 1-methoxy-2-ethoxyethane (5137-45-1) + methane (34557-54-5,27936-85-2) + Dimethyl ether (115-10-6,157621-61-9) + ethyl methyl ether (540-67-0) + 2-methoxy-ethanol (109-86-4,95507-80-5) + 2-methoxyethyl vinyl ether (1663-35-0)

Guidance literature:

at 16 ℃; Irradiation; Inert atmosphere;

DOI:10.1134/S0018143918040173

Reference yield:

diethylene glycol dimethyl ether (111-96-6) → methanol (67-56-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,2-dimethoxyethane (110-71-4) + methoxyethene (107-25-5,9003-09-2) + 1-methoxy-2-ethoxyethane (5137-45-1) + 2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) + methane (34557-54-5,27936-85-2) + Dimethyl ether (115-10-6,157621-61-9) + ethyl methyl ether (540-67-0) + 2-methoxy-ethanol (109-86-4,95507-80-5) + 2-methoxyethyl vinyl ether (1663-35-0)

Guidance literature:

at 163 ℃; Irradiation; Inert atmosphere;

DOI:10.1134/S0018143918040173

upstream raw materials:

trimethyl phosphite

2-ethoxy-ethanol

methyl iodide

ethyl bromide

Refernces

• 1、 Vlasov,Kholodkova,Ponomarev. "Influence of Boiling on the Radiolysis of Diglyme". . p. 312 - 318. Retrieved 2018/08/01.
• 2、 Van Dyke Tiers, George. "Direct methylation of primary and secondary alcohols by trimethyl phosphate to prepare pure alkyl methyl ethers". . p. 1223 - 1233. Retrieved 2007/10/03.