2-Phenylmorpholine

Base Information

• Chemical Name: 2-Phenylmorpholine
• CAS No.: 23972-41-0
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Hs Code.: 2934999090
• European Community (EC) Number: 819-506-5
• DSSTox Substance ID: DTXSID70946825
• Nikkaji Number: J1.607.234F
• ChEMBL ID: CHEMBL4069068
• Mol file: 23972-41-0.mol

Synonyms:2-Phenylmorpholine;23972-41-0;Morpholine, 2-phenyl-;2-Phenyl-morpholine;1448CERM;A 56;MFCD01713554;2-Phenyltetrahydro-1,4-oxazin [German];2-Phenyltetrahydro-1,4-oxazin;MFCD18249849;MFCD20278301;ChemDiv2_001813;Oprea1_030530;SCHEMBL357358;F2189-0303;CHEMBL4069068;DTXSID70946825;HMS1374C09;AMY21634;AZB37602;STK024781;AKOS001430835;AKOS016049789;AB09828;SB32003;SB36011;BS-13628;LS-93278;SY018079;SY025491;SY240389;BB 0262297;CS-0067845;FT-0683197;EN300-29447;F13476;A817013;Z283821656;1-[(tert-butyl)oxycarbonyl]-3-[4-(trifluoromethyl)benzyl]piperidine-3-carboxylic

Chemical Property of 2-Phenylmorpholine

Chemical Property:

• Vapor Pressure: 0.00423mmHg at 25°C
• Boiling Point: 278.6°Cat760mmHg
• PKA: 8.52±0.40(Predicted)
• Flash Point: 107.3°C
• PSA: 21.26000
• Density: 1.034g/cm³
• LogP: 1.67630
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 132

Purity/Quality:

99% ^*data from raw suppliers

2-phenylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)C2=CC=CC=C2

Technology Process of 2-Phenylmorpholine

There total 12 articles about 2-Phenylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-((4-nitrophenyl)sulfonyl)-2-phenylmorpholine (953986-10-2) → 2-phenylmorpholine (23972-41-0)

Guidance literature:

With lithium hydroxide monohydrate; 1-thiopropane; In acetonitrile; at 25 ℃; for 2h;

DOI:10.1021/ja104168q

Reference yield: 99.0%

2-phenyl-4-(4-(trifluoromethyl)phenylsulfonyl)morpholine → 2-phenylmorpholine (23972-41-0)

Guidance literature:

With magnesium; In methanol; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo502416r

Reference yield: 67.5%

2-phenyl-4-(toluene-4-sulfonyl)morpholine (321977-41-7) → 2-phenylmorpholine (23972-41-0)

Guidance literature:

2-phenyl-4-(toluene-4-sulfonyl)morpholine; With sodium; In pentan-1-ol; at 100 ℃; for 3h;

With water; In pentan-1-ol; at 34 ℃;

DOI:10.1016/j.bmc.2008.11.030

upstream raw materials:

4-benzyl-2-phenyl-morpholine

bromobenzene

[2-bromo-1-(2-chloro-ethoxy)-ethyl]-benzene

N-(2-hydroxyethyl)-N-(2-hydroxy-2-phenylethyl)amine

Downstream raw materials:

4-[2-(2-phenylmorpholin-4-yl)propyl]phenol

Refernces

• 1、 Zhou, Ling,Tan, Chong Kiat,Zhou, Jing,Yeung, Ying-Yeung. "Facile, efficient, and catalyst-free electrophilic aminoalkoxylation of olefins: Scope and application". supporting information; experimental part. p. 10245 - 10247. Retrieved 2010/09/07.
• 2、 -. "Steroidal anaesthetics of the pregnane and 19-norpregnane series". . . Retrieved 2008/06/13.