N-(morpholin-4-yl)-4-nitrobenzenesulfonamide

Base Information

• Chemical Name: N-(morpholin-4-yl)-4-nitrobenzenesulfonamide
• CAS No.: 64308-51-6
• Molecular Formula: C10H13 N3 O5 S
• Molecular Weight: 287.2923
• Mol file: 64308-51-6.mol

Synonyms:NSC 5768

Chemical Property of N-(morpholin-4-yl)-4-nitrobenzenesulfonamide

Chemical Property:

• Vapor Pressure: 4.13E-09mmHg at 25°C
• Boiling Point: 472.9°Cat760mmHg
• Flash Point: 239.8°C
• Density: 1.52g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(morpholin-4-yl)-4-nitrobenzenesulfonamide

There total 5 articles about N-(morpholin-4-yl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-aminomorpholine (4319-49-7) + 4-nitrobenzenediazonium tetrafluoroborate (456-27-9) → N-morpholino-4-nitrobenzenesulfonamide (64308-51-6)

Guidance literature:

With 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; In acetonitrile; at 25 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1002/anie.201309851

Reference yield: 67.0%

1-aminomorpholine (4319-49-7) + 3,3-diethyl-1-(4-nitrophenyl)triaz-1-ene (10125-39-0) → N-morpholino-4-nitrobenzenesulfonamide (64308-51-6)

Guidance literature:

With boron trifluoride diethyl etherate; sulfur dioxide; In acetonitrile; at 60 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4cc03481c

Reference yield:

4-nitro-aniline (100-01-6,104810-17-5) → N-morpholino-4-nitrobenzenesulfonamide (64308-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 °C

1.2: 0 - 20 °C

2.1: sulfur dioxide; boron trifluoride diethyl etherate / acetonitrile / 3 h / 60 °C / Inert atmosphere; Schlenk technique

With hydrogenchloride; boron trifluoride diethyl etherate; sulfur dioxide; sodium nitrite; In water; acetonitrile;

DOI:10.1039/c4cc03481c

upstream raw materials:

1-aminomorpholine

4-Nitrobenzenesulfonyl chloride

4-nitrobenzenediazonium tetrafluoroborate

3,3-diethyl-1-(4-nitrophenyl)triaz-1-ene

Refernces

• 1、 Li, Wanfang,Beller, Matthias,Wu, Xiao-Feng. "Catalytic conversion of aryl triazenes into aryl sulfonamides using sulfur dioxide as the sulfonyl source". supporting information. p. 9513 - 9516. Retrieved 2014/08/18.