Pasiniazid

Base Information

• Chemical Name: Pasiniazid
• CAS No.: 2066-89-9
• Molecular Formula: C7H7NO3^.C6H7N3O
• Molecular Weight: 290.279
• Hs Code.: 2933399090
• European Community (EC) Number: 218-183-2
• NSC Number: 758447
• UNII: 83J17CN0MN
• DSSTox Substance ID: DTXSID50174700
• Wikidata: Q27269437
• NCI Thesaurus Code: C175185
• ChEMBL ID: CHEMBL1496806
• Mol file: 2066-89-9.mol

Synonyms:Fintosid;isoniazide 4-aminosalicylate;pasiniazide

Chemical Property of Pasiniazid

Chemical Property:

• Appearance/Colour: COA
• Vapor Pressure: 1.78E-06mmHg at 25°C
• Melting Point: 142-144°
• Boiling Point: 380.8 °C at 760 mmHg
• Flash Point: 184.1 °C
• PSA: 151.56000
• LogP: 2.03010
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Water
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 290.10150494
• Heavy Atom Count: 21
• Complexity: 280

Purity/Quality:

99% ^*data from raw suppliers

Pasiniazid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1N)O)C(=O)O.C1=CN=CC=C1C(=O)NN
• Uses: antibacterial (tuberculostatic) Pasiniazid is an antituberculous agents against several species of rapidly growing mycobacteria (RGM).
• Therapeutic Function: Antitubercular

Technology Process of Pasiniazid

There total 2 articles about Pasiniazid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoniazid (54-85-3,7640-37-1) + 4-Aminosalicylic acid (65-49-6) → isonicotinic acid hydrazide 4-aminosalicylate (2066-89-9)

Guidance literature:

With ethanol; for 0.333333h;

DOI:10.1039/c0ce00842g

Reference yield:

→ isonicotinic acid hydrazide 4-aminosalicylate (2066-89-9)

Guidance literature:

Na-p-aminosalicylat, 1. Amberlite IR-120, Me., 2. Isonicotinsaeurehydrazid;

upstream raw materials:

isoniazid

4-Aminosalicylic acid

Refernces

• 1、 Grobelny, Pawel,Mukherjee, Arijit,Desiraju, Gautam R.. "Drug-drug co-crystals: Temperature-dependent proton mobility in the molecular complex of isoniazid with 4-aminosalicylic acid". . p. 4358 - 4364. Retrieved 2011.