Luminol

Base Information

• Chemical Name: Luminol
• CAS No.: 521-31-3
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.162
• Hs Code.: 29339990
• European Community (EC) Number: 208-309-4
• NSC Number: 5064
• UNII: 5EXP385Q4F
• DSSTox Substance ID: DTXSID5024504
• Nikkaji Number: J9.432C
• Wikipedia: Luminol
• Wikidata: Q408061
• ChEMBL ID: CHEMBL442329
• Mol file: 521-31-3.mol

Synonyms:Luminol

Chemical Property of Luminol

Chemical Property:

• Appearance/Colour: yellow crystals or beige powder
• Melting Point: 319-320 °C
• Refractive Index: 1.6500 (estimate)
• Boiling Point: 621.9oC at 760 mmHg
• PKA: (Calcd.) 10.50 ± 0.20;;0.58 ± 0.20(at 25℃)
• Flash Point: 329.9oC
• PSA: 91.74000
• Density: 1.433 g/cm³
• LogP: 0.37980
• Storage Temp.: 0-6°C
• Solubility.: Solubility Insoluble in water, soluble in dimethyl sulfoxide, ba
• Water Solubility.: <0.1 g/100 mL at 19℃
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 177.053826475
• Heavy Atom Count: 13
• Complexity: 254

Purity/Quality:

99.0% min ^*data from raw suppliers

Luminol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22-20/21/22
• Safety Statements: 26-36/37-37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Dyes -> Indicator Dyes
• Canonical SMILES: C1=CC2=C(C(=C1)N)C(=O)NNC2=O
• Recent EU Clinical Trials: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, PROOF-OF-CONCEPT, PHASE IIA STUDY OF MP1032 PLUS STANDARD OF CARE VS STANDARD OF CARE IN THE TREATMENT OF HOSPITALIZED PATIENTS WITH MODERATE TO SEVERE COVID-19.
• Uses: 1.??? It can be used as chemical analysis reagents, indicators. 2.??? It can be used for chemiluminescence analysis such as measurement of metal cations, blood and glucocorticoids Luminol is a chemiluminescent probe that has been used to detect myeloperoxidase-mediated oxidative events in granulocytes and for chemiluminescence analysis of metal cations and blood. Detection of copper, iron, peroxides, cyanides. Luminol is used in the detection of copper, iron, peroxides and cyanides. It exhibits chemiluminescence and utilized to measure opsonic and phagocytic function. It acts as a biological sensor and involved in the detection of polymorphonuclear leukocytes response in a patient with a myeloperoxidase deficiency. Further, it is used as a forensic test for blood.

Technology Process of Luminol

There total 21 articles about Luminol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-nitro-2,3-dihydro-phthalazine-1,4-dione (3682-15-3) → 5-amino-2,3-dihydrophthalazine-1,4-dione (521-31-3)

Guidance literature:

With sulfur; sodium hydroxide; In methanol; water; at 80 ℃; for 1h; Green chemistry;

DOI:10.1002/ejoc.202000064

Reference yield: 82.0%

3-aminophthalimide (2518-24-3) → 5-amino-2,3-dihydrophthalazine-1,4-dione (521-31-3)

Guidance literature:

With hydrazine-hydroquinone complex; at 140 - 145 ℃; for 0.166667h; neat (no solvent);

DOI:10.3184/174751911X13058077114827

Reference yield: 70.0%

4-amino-2-methyl-1H-isoindole-1,3(2H)-dione (2257-85-4) → 5-amino-2,3-dihydrophthalazine-1,4-dione (521-31-3)

Guidance literature:

With hydrazine hydrate; at 110 ℃;

DOI:10.1515/znb-2004-0411

upstream raw materials:

2,4-diaminoisoindoline-1,3-dione

ethyl 2-carboxy-3-nitrobenzoate

5-aminophthalazine-1,4-dione

3-aminophthalimide

Downstream raw materials:

3-aminophthalate dianion

5-aminophthalazine-1,4-dione

5-(2-chloro-acetylamino)-2,3-dihydro-phthalazine-1,4-dione

triethylamine hydrochloride

Refernces

• 1、 Cerecetto, Hugo,Romero, Angel H.. "A Common, Facile and Eco-Friendly Method for the Reduction of Nitroarenes, Selective Reduction of Poly-Nitroarenes and Deoxygenation of N-Oxide Containing Heteroarenes Using Elemental Sulfur". . . Retrieved 2020/03/23.
• 2、 -. "CRYSTALLINE FORM OF 5-AMINO-2,3-DIHYDROPHTHALAZINE-1,4-DIONE". Page/Page column 23; 24. . Retrieved 2017/09/08.