6-KETOESTRADIOL

Base Information

• Chemical Name: 6-KETOESTRADIOL
• CAS No.: 571-92-6
• Molecular Formula: C18H22O3
• Molecular Weight: 286.371
• Hs Code.: 2937230000
• Mol file: 571-92-6.mol

Synonyms:Estra-1,3,5(10)-trien-6-one,3,17b-dihydroxy- (8CI);1,3,5(10)-Estratrien-3,17b-diol-6-one;3,17b-Dihydroxyestra-1,3,5(10)-trien-6-one;6-Ketoestradiol;6-Oxo-17b-estradiol;6-Oxoestradiol;6-keto-17b-Estradiol;NSC 147966;

Chemical Property of 6-KETOESTRADIOL

Chemical Property:

• Vapor Pressure: 5.59E-10mmHg at 25°C
• Melting Point: 281-283°C
• Refractive Index: 1.611
• Boiling Point: 478.9°Cat760mmHg
• PKA: 9.36±0.60(Predicted)
• Flash Point: 257.5°C
• PSA: 57.53000
• Density: 1.249g/cm³
• LogP: 3.24940
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

6-Keto17β-Estradiol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 6-KETOESTRADIOL

There total 40 articles about 6-KETOESTRADIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-oxoestra-1,3,5(10)-triene-3,17β-diyl dipropionate (147802-61-7) → 6-ketoestradiol (571-92-6)

Guidance literature:

With potassium hydroxide; In ethanol; for 1.5h; Heating;

DOI:10.1016/0040-4020(95)00871-5

Reference yield: 92.0%

6-oxo-3,17β-estradiol diacetate (3434-45-5) → 6-ketoestradiol (571-92-6)

Guidance literature:

With potassium hydroxide; In methanol; for 24h; Ambient temperature;

Reference yield: 88.0%

C20H26O4 → 6-ketoestradiol (571-92-6)

Guidance literature:

C₂₀H₂₆O₄; With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; toluene; at 25 - 30 ℃; for 2h;

With methanol; sodium hydroxide; In dichloromethane; toluene; at 20 ℃; for 2h;

upstream raw materials:

6-oxo-3,17β-estradiol diacetate

Estra-1,3,5(10),6-tetraene-3,6,17β-triol Triacetate

6-oxoestra-1,3,5(10)-triene-3,17β-diyl dipropionate

3,17β-bis(2-tetrahydropyranyloxy)estra-1,3,5(10)-triene-6-one

Downstream raw materials:

6β-hydroxyestradiol

3,17β-bis(2-tetrahydropyranyloxy)estra-1,3,5(10)-triene-6-one

fulvestrant

(+)-(7α)-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol

Refernces

• 1、 Zhao, Lei-Min,Meng, Qing-Yuan,Fan, Xiang-Bing,Ye, Chen,Li, Xu-Bing,Chen, Bin,Ramamurthy, Vaidhyanathan,Tung, Chen-Ho,Wu, Li-Zhu. "Photocatalysis with Quantum Dots and Visible Light: Selective and Efficient Oxidation of Alcohols to Carbonyl Compounds through a Radical Relay Process in Water". . p. 3020 - 3024. Retrieved 2017/03/13.
• 2、 -. "PROCESS FOR PREPARING 7-ALPHA-[9-(4,4,5,5,5-PENTAFLUOROTHIOPENTYL) NONYL]ESTRA-1,3,5(10)-TRIENE-3,17-BETA-DIOL". Paragraph 0044; 0045; 0046; 0047; 0048. . Retrieved 2014/09/02.